1. Dynamic contrast enhanced MRI of the placenta: A tool for prenatal diagnosis of placenta accreta? 
A.E. Millischer, B. Deloison, S. Silvera, Y. Ville, N. Boddaert, D. Balvay, N. Siauve, C.A. Cuenod, V. Tsatsaris, L. Sentilhes, L.J. Salomon 
Placenta 
Volume 53, Pages (May 2017)
DOI: /j.placenta
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2. Fig. 1 Definition of regions of interest (ROIs).
Figure 1a: Sagittal SSFP: placental tissue that displayed a heterogeneous pattern (arrowhead) (Suspected Accreta Area) in comparison to the upper anterior side of the placenta (white arrow) (Control Area) Placenta accreta was confirmed at delivery in this case.
Figure 1b: ROIs were placed in the Control Area (yellow ROI) and the Suspected Accreta Area (red ROI). Enhanced MRI image.
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3. Fig. 2
The three parameters characterizing the placental enhancement curve: Maximal Signal Intensity, Time To Peak, Area Under the Enhancement Curve (first 2 min).
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4. Fig. 3
Example of two different types of enhancement: ROIs from which the curves were extracted.
A- Placenta Accreta: enhancement curves differ between Suspected Accreta Area and Control Area.
B- Placenta non Accreta: enhancement curves are similar between Suspected Accreta Area and Control Area.
- Blue = Suspected Accreta Area ROI, Red = Control Area ROI.
- lag time to peak (Δt), defined as (Time of peak CA- Time of peak SAA) (sec).
- Log ratio of Max SI (LogrMax) defined as Log (Max SI SAA/Max SI CA).
- and Log ratio of Area Under the enhancing Curve (LogrAUC), defined as Log (AUC SAA/AUC CA).
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5. Fig. 4
Microvascular parameters (mean, SE and mean ± 1.96SE) in the accreta (right) and normal low-lying placenta (left). a: Δt, b:LogrAUC, c: LogrMax. All differences significant (p < 10−3).
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6. Fig. 5
Enhancement features of the placenta: ROC curves for the three parameters: a: Δt, b: LogrMax, c: LogrAUC.
Placenta  , 40-47DOI: ( /j.placenta )
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7. Fig. 6
Probability (and 95% CI) of accreta according to the three parameters. a: Δt, b:LogrAUC, c: LogrMax.
Placenta  , 40-47DOI: ( /j.placenta )
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