1. Test Yourself!!! Microtubule Test Intermediate filament test
Microfilament Test
Malfunction Test

2. Begin Microtubule Test

3. All Microtubule organising centres (MTOCs) share a common protein known as?
Actin
B) Myosin
C) Tubulin
D) γ-Tubulin

4. All Microtubule organising centres (MTOCs) share a common protein known as?
Actin
B) Myosin
C) Tubulin
D) γ-Tubulin

5. Tubulin monomers are arranged into longitudinal rows known as?
A) Protofilaments
B) Microfilaments
C) Centrosomes
D) Macula Densa

6. Tubulin monomers are arranged into longitudinal rows known as?
A) Protofilaments
B) Microfilaments
C) Centrosomes
D) Macula Densa

7. All of the following are functions of the microtubules EXCEPT:
A) They provide a track for the movement of vesicles through the cell
B) They help the cell resist compression
C) They pull chromosome pairs apart during cell division
D) They anchor proteins to the cell's surface

8. All of the following are functions of the microtubules EXCEPT:
A) They provide a track for the movement of vesicles through the cell
B) They help the cell resist compression
C) They pull chromosome pairs apart during cell division
D) They anchor proteins to the cell's surface

9. What is a property shared by the assembly of tubulin and actin monomers into their respective polymers?
A) The assembly component subunit is a protein monomer
B) The subunit must have ATP bound in order to assemble
C) Nucleotide bound to subunit is hydrolyzed after assembly of the subunit
D) An enzyme is needed for assembly

10. What is a property shared by the assembly of tubulin and actin monomers into their respective polymers?
A) The assembly component subunit is a protein monomer
B) The subunit must have ATP bound in order to assemble
C) Nucleotide bound to subunit is hydrolyzed after assembly of the subunit
D) An enzyme is needed for assembly

11. Which of the following is NOT a correct statement about cytoskeletal motor proteins?
A) They are all ATPases.
B) All microtubule associated motor proteins move toward the plus end of the microtubule.
C) Each of them has at least one globular head domain containing a cytoskeleton binding site.
D) Each of them is capable of movement in only one direction along a cytoskeletal polymer.

12. Which of the following is NOT a correct statement about cytoskeletal motor proteins?
A) They are all ATPases.
B) All microtubule associated motor proteins move toward the plus end of the microtubule.
C) Each of them has at least one globular head domain containing a cytoskeleton binding site.
D) Each of them is capable of movement in only one direction along a cytoskeletal polymer.

13. The motor protein responsible for ciliary and flagella motility is located at the structure labelled with the letter?
A) A
B) B
C) C
D) D

14. The motor protein responsible for ciliary and flagella motility is located at the structure labelled with the letter?
A) A
B) B
C) C
D) D
These are the dynein arms, which contain the dynein motor protein, an ATPase which is responsible for doublet microtubule sliding, which is the basis for ciliary and flagellar motility

15. End of Microtubule test! Return to start menu
Continue to Intermediate filament Test

16. Intermediate filaments are connected to other cytoskeletal filaments by thin wispy bridges known as?
A) Amylopectin
B) Plectin
C) Myosin
D) Dyenin

17. Intermediate filaments are connected to other cytoskeletal filaments by thin wispy bridges known as?
A) Amylopectin
B) Plectin
C) Myosin
D) Dyenin

18. Intermediate filaments help to maintain the position of what organelle within the cell?
A) Nucleus
B) Mitochondria
C) Lysosomes
D) Ribosomes

19. Intermediate filaments help to maintain the position of what organelle within the cell?
A) Nucleus
B) Mitochondria
C) Lysosomes
D) Ribosomes

20. Which of the following is NOT an Intermediate filament protein?
A) Vimentin
B) Actin
C) NF-L
D) Nestin

21. Which of the following is NOT an Intermediate filament protein?
A) Vimentin
B) Actin
C) NF-L
D) Nestin

22. Which of the following images illustrates the assembly of intermediate filaments?
A) A B) B
C) C

23. Which of the following images illustrates the assembly of intermediate filaments?
A) A B) B
C) C

24. Which of the following best describes intermediate filaments?
A) Long, hollow unbranched tubes composed of subunits of the protein tubulin.
B) Solid, thinner structures, often organized into a branching network and composed of the protein actin.
C) Tough, rope-like fibres composed of a variety of related proteins
D) Any of a class of nitrogenous organic compounds which have large molecules composed of one or more long chains of amino acids

25. Which of the following best describes intermediate filaments?
A) Long, hollow unbranched tubes composed of subunits of the protsin tubulin.
B) Solid, thinner structures, often organized into a branching network and composed of the protein actin.
C) Tough, rope-like fibres composed of a variety of related proteins
D) Any of a class of nitrogenous organic compounds which have large molecules composed of one or more long chains of amino acids

26. Which of the following statements is correct about intermediate filaments ?
A) Composed of asymmetric building blocks (tetrameric subunits)
B) Composed of symmetric building blocks (tetrameric subunits)
C) Composed of globular proteins arranged in longitudinal rows (protofilaments)

27. Which of the following statements is correct about intermediate filaments ?
A) Composed of asymmetric building blocks (tetrameric subunits)
B) Composed of symmetric building blocks (tetrameric subunits)
C) Composed of globular proteins arranged in longitudinal rows (protofilaments)

28. Which types of intermediate filaments are described as keratins?
A) Type I and II
B) Type II and III
C) Type III and IV
D) Type IV and V

29. Which types of intermediate filaments are described as keratins?
A) Type I and II
B) Type II and III
C) Type III and IV
D) Type IV and V

30. End of Intermediate filament test! Return to start menu
Continue to Microfilament Test

31. Microfilaments are also known as?
A) Myosin filaments
B) Amylopectin filaments
C) Actin Filaments
D) Mannose Filaments

32. Microfilaments are also known as?
A) Myosin filaments
B) Amylopectin filaments
C) Actin Filaments
D) Mannose Filaments

33. Both ends of an actin filament can gain or lose subunits but the preferred site of addition of sub units is the ……… end?
A) Minus (-)
B) Plus (+)

34. Both ends of an actin filament can gain or lose subunits but the preferred site of addition of sub units is the ……… end?
A) Minus (-)
B) Plus (+)

35. Which of these statements is correct regarding microfilaments?
A) They play a key role in contractility and motility within cells
B) They play a key role in maintaining cell shape and size
C) They require GTP for actin to be incorporated onto the growing end

36. Which of these statements is correct regarding microfilaments?
A) They play a key role in contractility and motility within cells
B) They play a key role in maintaining cell shape and size
C) They require GTP for actin to be incorporated onto the growing end

37. Which of these is NOT an inhibitor used in studies with the aim of disrupting dynamic Microfilament based activities?
A) Cytochasalin
B) Phallodin
C) Latrunculin
D) Tetracyclin

38. Which of these is NOT an inhibitor used in studies with the aim of disrupting dynamic Microfilament based activities?
A) Cytochasalin
B) Phallodin
C) Latrunculin
D) Tetracyclin

39. Which of the statements below best describes microfilament tread milling?
A) Equilibrium between the rate of monomer addition and net loss of subunits at the plus and minus ends of the filament
B) Greater rate of subunit addition at the plus end than subunit loss at the minus end of filament
C) Greater rate of subunit loss at the minus end than net addition at the plus end of the filament
D) Actin filaments appear to be on a treadmill

40. Which of the statements below best describes microfilament tread milling?
A) Equilibrium between the rate of monomer addition and net loss of subunits at the plus and minus ends of the filament
B) Greater rate of subunit addition at the plus end than subunit loss at the minus end of filament
C) Greater rate of subunit loss at the minus end than net addition at the plus end of the filament
D) Actin filaments appear to be on a treadmill

41. Individual actin monomers are also known as G-Actin, what does the ‘G’ mean?
A) Myosin filaments
B) Amylopectin filaments
C) Actin Filaments
A) Globular B) Glomerular C) Global D) Glacial

42. Individual actin monomers are also known as G-Actin, what does the ‘G’ mean?
A) Myosin filaments
B) Amylopectin filaments
C) Actin Filaments
A) Globular B) Glomerular C) Global D) Glacial

43. The ABP that binds actin filaments together to form the parallel bundle organization is?
A) Myosin
B) Cohesin
C) Fimbrin
D) Kinesin

44. The ABP that binds actin filaments together to form the parallel bundle organization is?
A) Myosin
B) Cohesin
C) Fimbrin
D) Kinesin

45. End of Microfilament test! Return to start menu
Continue to Malfunction Test

46. Decreased contractile filaments of sarcomere
Cytoskeleton Quiz
Which of the following dysfunctions is not associated with Heart Disease?
Decreased contractile filaments of sarcomere
B) Impaired B-adrenergic receptor signalling
C) Mutations in genes encoding thick filament proteins in myosin heavy chains
D) Decreased proteins and tubulin
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47. Decreased contractile filaments of sarcomere
Cytoskeleton Quiz
Which of the following dysfunctions is not associated with Heart Disease?
Decreased contractile filaments of sarcomere
B) Impaired B-adrenergic receptor signalling
C) Mutations in genes encoding thick filament proteins in myosin heavy chains
D) Decreased proteins and tubulin
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48. Tau protein accumulation B) Ezrin C) Cofilin- Actin Rod Formation
Cytoskeleton Quiz
Which of the following is NOT a pathology related with Alzheimer's disease?
Tau protein accumulation
B) Ezrin
C) Cofilin- Actin Rod Formation
D) Presence of Hirano bodies
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49. Tau protein accumulation B) Ezrin C) Cofilin- Actin Rod Formation
Cytoskeleton Quiz
Which of the following is NOT a pathology related with Alzheimer's disease?
Tau protein accumulation
B) Ezrin
C) Cofilin- Actin Rod Formation
D) Presence of Hirano bodies
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50. Intermediate filaments function for all of the following except?
Cytoskeleton Quiz
Intermediate filaments function for all of the following except?
Cell movement
B) Anchoring at plasma membrane
C) Support against mechanical stress
D) Cell signalling
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51. Intermediate filaments function for all of the following except?
Cytoskeleton Quiz
Intermediate filaments function for all of the following except?
Cell movement
B) Anchoring at plasma membrane
C) Support against mechanical stress
D) Cell signalling
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52. Cytoskeleton Quiz
Indicate which of the panels, A, B, C, D or E show the two hallmarks of Alzheimer’s disease (B-amyloid plaques and Neurofibrillary tangles)?
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53. Cytoskeleton Quiz
Indicate which of the panels, A, B, C, D or E show the two hallmarks of Alzheimer’s disease (B-amyloid plaques and Neurofibrillary tangles)?
The arrows on panel A indicate beta amyloid plaques and neurofibulary tangles
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54. Cytoskeleton Quiz
Which of the following is not a characteristic of Duchenne muscular dystrophy?
Progressive muscle weakness
B) Wasting away of certain muscle groups
C) Affects mostly females
D) The altered product is dystrophin
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55. Cytoskeleton Quiz
Which of the following is not a characteristic of Duchenne muscular dystrophy?
Progressive muscle weakness
B) Wasting away of certain muscle groups
C) Affects mostly females
D) The altered product is dystrophin
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56. D) Some forms of anaemia
Cytoskeleton Quiz
Which of the following diseases is not as a result of cytoskeletal malfunction?
Alzheimer’s disease
B) Metastatic cancers
C) Diabetes Mellitus
D) Some forms of anaemia
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57. D) Some forms of anaemia
Cytoskeleton Quiz
Which of the following diseases is not as a result of cytoskeletal malfunction?
Alzheimer’s disease
B) Metastatic cancers
C) Diabetes Mellitus
D) Some forms of anaemia
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58. End of Malfunction Test!
Cytoskeleton Quiz
End of Malfunction Test!
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When things go wrong
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