1. © The Author(s) 2015. Published by Science and Education Publishing.
Table 3. Effect of different treatments on catalase (CAT), malondialdehyde (MDA), myeloperoxidase (MPO), tumor
necrosis factor alpha (TNF-α), transforming growth factor beta 1 (TGF-β1) and histological disease score
Control
UC patients before treatment
UC patients treated with metformin
UC patients treated with I3C
UC patients treated with metformin/I3C combination
Tissue CAT (μmol/g tissue)
2.23±0.0 5
0.89±0.04a
(p=0.03)
1.53±0.05b
(p=0.029)
1.4±0.06b
(p=0.033)
1.81±0.05bcd
(p1=0.025; p2=0.043; p3=0.04)
Tissue MDA (nmol/g tissue)
18.3±0.7
43.1±0.81a
(p=0.022)
28.51±0.5b
(p=0.019)
26.4±0.8 b
(p=0.018)
22.2±0.6bcd
(p1=0.016; p2=0.032; p3=0.038)
Tissue MPO (U/g tissue)
72.2 ±3.6
165.1±5.8a
(p=0.02)
112.6±4.2b
123.4±4.15 b
(p=0.037)
91.5±5.6bcd
(p1=0.021; p2=0.042; p3=0.037)
Tissue TNF-α (pg/mg protein)
67.4±4.1
385.6±9.6a
(p=0.007)
195.3±7.4b
(p=0.024)
253.2±8.1b
(p=0.032)
149.8±6.3bcd
(p1=0.018; p2=0.04; p3=0.032)
Tissue TGF-β1 (pg/μg protein)
7.4±0.4
33.2±0.8a
(p=0.016)
21.1±0.6b
(p=0.035)
23.6±0.7 b
(p=0.036)
16.2±0.4bcd
(p1=0.016; p2=0.039; p3=0.035)
Histological disease score
0.00
2.03±0.06a
(p<0.001)
0.8±0.03b
(p=0.023)
1.12±0.04b
0.54±0.03bcd
(p1=0.015; p2=0.03; p3=0.04)
a Significant compared to the control group (p<0.05)
b Significant compared to UC patients before treatment (p<0.05)
c Significant compared to UC patients treated with metformin (p<0.05)
d Significant compared to UC patients treated with I3C (p<0.05)
P1 refers to metformin/I3C combination group compared to UC patients before treatment; P2 refers to metformin/I3C combination g
roup compared to UC patients treated with metformin; P3 refers to metformin/I3C combination group compared to UC patients treated with I3C.
Ahmed M. Kabel et al. Effect of Indole-3-carbinol and/or Metformin on Female Patients with Ulcerative Colitis
(Premalignant Condition): Role of Oxidative Stress, Apoptosis and Proinflammatory Cytokines. Journal of Cancer
Research and Treatment, 2017, Vol. 5, No. 1, 1-8. doi: /jcrt-5-1-1
© The Author(s) Published by Science and Education Publishing.