1. Pathophysiologic effects of As5+ (As5+; arsenate)
Pathophysiologic effects of As5+ (As5+; arsenate). (A) Arsenate (chemical formula AsO43–) substitutes for inorganic phosphate (Pi; * indicates substitutions), bypassing the formation of 1,3-bisphosphoglycerate (1,3-BPG), and thus losing the ATP formation that occurs when 1,3-BPG is metabolized to 3-phosphoglycerate. (B) Energy loss also occurs if arsenate substitutes for Pi and blocks the formation of ATP from ADP. ADP = adenosine diphosphate; ATP = adenosine triphosphate.
Source: Arsenic, Goldfrank's Toxicologic Emergencies, 10e
Citation: Hoffman RS, Howland M, Lewin NA, Nelson LS, Goldfrank LR. Goldfrank's Toxicologic Emergencies, 10e; 2015 Available at: Accessed: December 19, 2017
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