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Cell Division Mitosis and Meiosis
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DNA deoxyribonucleic acid
DNA contains the genetic instructions for our cells. deoxyribonucleic acid
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Chromosomes Chromosomes are made of strands of DNA
Most human cells have 46 chromosomes. A cell with all of the chromosomes present is called diploid
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Chromatin Chromatin is chromosomes paired with proteins
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Cell division in prokaryotes
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Cell division in eukaryotes- The Cell Cycle
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G1 Phase: Cell growth This is when cells grow Increase in size
Make new proteins and organelles
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S-phase- DNA replication
DNA is synthesized when chromosomes are copied
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G2-phase: preparing for cell division
Organelles are made Molecules are produced
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M phase: Cell Division Mitosis – this is when the cell actually divides! Steps in Mitosis: Prophase – Metaphase – Anaphase - Telophase
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prophase The chromosomes condense and become visible
The centrioles form and move toward opposite ends of the cell ("the poles") The nuclear membrane dissolves The mitotic spindle forms
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metaphase The Centrioles complete their migration to the poles
The chromosomes line up in the middle of the cell ("the equator")
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Anaphase Mitotic spindles begin to shorten, pulling chromatids apart
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telophase The chromosomes decondense The nuclear envelope forms
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Cytokinesis Cell membrane pinches in to form two cells
These cells are now in interphase
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Regulating Cell growth
What controls cell growth? Cells in contact with each other usually stop dividing, however many other factors are at work including: Cyclin - a protein that signals a cell to begin reproducing Internal & External regulators
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Internal regulators Proteins in the cell that regulate mitosis, making sure that each phase is completed before the next phase begins
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External regulators Proteins that respond to events to outside of the cell Growth – signal to a cell to begin mitosis when certain events occur like: Cuts, breaks, scratches
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Apoptosis – programmed cell death
Some cells contain instructions in the DNA that control when the cell will die Chromatin shrinks, the cell membrane breaks apart and then the cell is digested by other cells
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Cancer What is cancer? Unregulated cell growth caused by cells losing control of cellular division Uncontrolled cell division
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Tumors A mass of cells that have divided uncontrolled
Benign tumors: non-cancerous, meaning that they will not spread (localized) Malignant tumors: cancerous, meaning that the cells may, have or will spread
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What causes cancer? Defects in the genes that regulate and control cell division Can be caused by: Environmental Factors Genetic Factors
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Cancer treatments Not all cancer types are treatable
Advanced stages of cancer are often too far gone to treat Treatments include Surgery Radiation Chemotherapy Stem Cells
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