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Protective effects of telmisartan on ischemia/reperfusion injury of rat ovary: biochemical and histopathologic evaluation  Yakup Kumtepe, M.D., Fehmi.

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Presentation on theme: "Protective effects of telmisartan on ischemia/reperfusion injury of rat ovary: biochemical and histopathologic evaluation  Yakup Kumtepe, M.D., Fehmi."— Presentation transcript:

1 Protective effects of telmisartan on ischemia/reperfusion injury of rat ovary: biochemical and histopathologic evaluation  Yakup Kumtepe, M.D., Fehmi Odabasoglu, Ph.D., Mehmet Karaca, M.D., Beyzagul Polat, M.Sc., Mesut Bünyamin Halici, Ph.D., Osman Nuri Keles, M.Sc., Zuhal Altunkaynak, Ph.D., Fatma Gocer, M.D.  Fertility and Sterility  Volume 93, Issue 4, Pages (March 2010) DOI: /j.fertnstert Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

2 Figure 1 Effects of ischemia (ISC) and ischemia/reperfusion (ISC+REP) plus telmisartan (T) treatments on changes in activities of superoxide dismutase (SOD) (A), inducible nitric oxide synthase (iNOS) and myeloperoxidase (MPO) (B) in ovaries of rats. Results are shown as mean ± SEM, and the measurements were calculated from three replicates. Each group included six rats. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

3 Figure 2 Light micrographs of ischemia group. CH = corpus hemorrhagicum; E = edema; F = fibrin accumulation; GC = granulosa cells; H = hemorrhage; MI = mononuclear cell infiltration. Arrow = edematous spaces among the follicle cells. Boxed or circled areas = abnormally shaped follicles and oocyte, respectively.Scale bars = 50 μm. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

4 Figure 3 Light micrographs of ischemia plus 20 mg telmisartan group. CH = corpus hemoragicum; mi = mitotic figure; sf = secondary follicle. Scale bars = 20 μm. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

5 Figure 4 Light micrographs of ischemia/reperfusion group. AF = atretic follicle; CL = corpus luteum; H = hemorrhage; f = fibroblast; Ln = lymphatic nodule; m = macrophage; mc = mast cell; pc = plasma cell; WA = white adipocyte. Scale bars = 20 μm. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

6 Figure 5 Light micrographs of ischemia/reperfusion plus 10 mg telmisartan group. Abbreviations as in Figure 4. Scale bars: 50 μm. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

7 Figure 6 Light micrographs of ischemia/reperfusion plus 20 mg telmisartan group. Abbreviations as in Figure 4. Scale bars: 50 μm. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions


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