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Organic chemistry A Chapter 7 Role of the solvent By Prof. Dr. Adel M

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1 Organic chemistry A Chapter 7 Role of the solvent By Prof. Dr. Adel M
Organic chemistry A Chapter 7 Role of the solvent By Prof. Dr. Adel M. Awadallah Islamic University of Gaza

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4 Solubility of organic compounds

5 Protic and aprotic solvents Protic solvents are solvents containing hydrogen that is attached to oxygen or nitrogen. They solvate cations through unshared pairs, and anions throaugh hydrogen bonding Examples : water, methanol, ethanol , acids

6 Aprotic solvents: Solvents that do not contain acidic hydrogens, They dissolve ionic compounds chiefly through their solvation of cations. The positive charge of the solvent is buried within the molecule

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8 Effect of protic solvents in SN1 Reactions

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10 Effect of protic solvents in SN2 Reactions

11 SN2 reactions (with negative nucleophiles) in aprotic solvents go as much as a million times faster than in alcohol or an alcohol-water mixture

12 The SN2 reaction: Phase-transfer catalysis

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