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Organic chemistry A Chapter 7 Role of the solvent By Prof. Dr. Adel M
Organic chemistry A Chapter 7 Role of the solvent By Prof. Dr. Adel M. Awadallah Islamic University of Gaza
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Solubility of organic compounds
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Protic and aprotic solvents Protic solvents are solvents containing hydrogen that is attached to oxygen or nitrogen. They solvate cations through unshared pairs, and anions throaugh hydrogen bonding Examples : water, methanol, ethanol , acids
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Aprotic solvents: Solvents that do not contain acidic hydrogens, They dissolve ionic compounds chiefly through their solvation of cations. The positive charge of the solvent is buried within the molecule
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Effect of protic solvents in SN1 Reactions
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Effect of protic solvents in SN2 Reactions
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SN2 reactions (with negative nucleophiles) in aprotic solvents go as much as a million times faster than in alcohol or an alcohol-water mixture
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The SN2 reaction: Phase-transfer catalysis
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