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MOSCOW INFANTS: ATOPIC DERMATITIS,
SKIN REACTIONS TO THE DIETARY INTAKE AT 1-YEAR OF AGE FOLLOWED TO 2-YEARS OF AGE AND SENSITIZATION AT THE AGE OF 1 YEAR Imperial College London Pirogov Russian National Research Medical University Marina Treneva1, Daniel Munblit 2, Alexander Pampura1 Research and Clinical Institute for Pediatrics (Moscow) 1 Research and Clinical Institute for Pediatrics at the Pirogov Russian National Research Medical University, Moscow, Russia 2 Imperial College London, London, United Kingdom Background: Atopic dermatitis (AD) incidence may be compared in cohorts evaluated with standardized questionnaires. Up to our knowledge, AD prevalence in Russia, using UK Working Party's Diagnostic Criteria for Atopic Dermatitis have never been tested. Methods: 393 infants were recruited at Postnatal Department of Moscow No.1 Maternity Hospital in 2011. All newborns and their mothers were admitted to the Department within the 48 hours prior to their enrollment. A year later 363 mothers (92,4 %) were questioned using UK Working Party's Diagnostic Criteria for Atopic Dermatitis. Two years later 353 mothers of 393 (89,8 %) agreed to answer the questions. Cheeks/body hyperemia and/or skin rash were also assessed in 365 children at 1 year and in 355 at 2 years of age. Infantile diet and maternal food intake during breastfeeding were recorded. Sensitization at the age of one was investigated in 130 children using skin prick-tests to D.pteronissinus, Alternaria, cat, birch pollen, 5 grass pollen, egg, cod fish, peanut (all by Stallergens) and milk (produced by ALK). Objective: To evaluate AD incidence in Moscow in a cohort of children recruited in general population, assessing them at one and two years using UK Working Party's Diagnostic Criteria for Atopic Dermatitis. Results: Using UK Working Party's Diagnostic Criteria we diagnosed AD in 2,2% children (8 of 363) at 1 year and in 4,2 % (15 of 353) at 2 years of age. One or more episode of cheeks/body hyperemia and/or skin rash during the first year of life was reported in 45,8 % and in 36,9 % during the second year of life. Wheal 3 mm or more to at least one of nine allergens was in 5,4 % of children at 1 year of age. Conclusion: According to our data, only a small amount of one and two year old children in Moscow can be diagnosed with AD when using UK Working Party's Diagnostic Criteria for Atopic Dermatitis, especially in comparison to a number of children with reported skin reactions to foods.
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