1. Professor of oncology Faculty of medicine
Anthracyclines
Presented by: Dalia Refat
Marwa el-ashwah
Noha el-bassiouny
Nortan Hashad
Samer EL-rouweny
and
Yomna Mamdouh
Supervised by:
Proff.Nashaat Lotfy
Professor of oncology Faculty of medicine

2. Content:
Definition
Mechanism of action
Indications

3. Definition: It’s a class of antineoplastic antibiotics.
The first anthracycline discovered was daunorubicin (trade name Daunomycin), which was produced naturally by Streptomyces bacteria.
Doxorubicin (Adriamycin) was developed shortly after, and many other related compounds have followed.

4. Daunorubicin Doxorubicin Epirubicin Idarubicin Valrubicin Mitoxantrone
Trade name
Drug
Daunomycin, Daunoxome
Daunorubicin
Adriamycin, Doxil
Doxorubicin
Pharmorubicin
Epirubicin
Zavidos
Idarubicin
Valstar
Valrubicin
Novantrone
Mitoxantrone
Bleocin
Bleomycin

6. Mechanism of action:
They are Non Cell Cycle specific antibiotics, that act on S and G2 phase.

7. Through three mechanisms:
Intercalate into DNA resulting in inhibition of it’s synthesis and function.
Inhibits topoisomerase II enzyme by forming a cleavable complex with DNA and topoisomerase II to create uncompensated DNA helix leading to DNA breakage.

8. Formation of cytotoxic oxygen free radicals results in single and double stranded DNA breakage.

9. AIDS-related Kaposi’s sarcoma
Indications:
Doxorubicin and Daunorubicin Acute leukemia, Hodgkin's and non Hodgkin’s lymphoma.
Doxorubicin
(liposomal form)
AIDS-related Kaposi’s sarcoma
Ovarian cancer

10. Epirubicin Breast Cancer
Idarubicin Hematological disorder (AML)
Valrubicin Bladder Cancer
Mitoxantrone Metastatic Breast Cancer, Leukemia and Prostatic Cancer

11. Bleomycin Squamous cell carcinoma, lymphoma and Testicular carcinoma