1. Jessica Fredericks;Ruibao Ren ;
The role of RAS effectors in BCR/ABL induced chronic myelogenous leukemia
Jessica Fredericks;Ruibao Ren ;
State Key Laboratory for Medical Genomics, Shanghai Institute of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai , China; Rosenstiel Basic Medical Sciences Research Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA ;
Fig.1 Expression of BCRABL Y177F plus oncogenic NRASG12D induces CML-like MPD. A Schematic representation of retroviral MSCV constructs used in a mouse BMT experiment. B Kaplan-Meier analysis: cumulative survival of mice receiving each of the MSCV constructs. BM was infected with matched viral titers of 4×10 5 TU to 5×10 5 TU per construct. C Representative FACS analysis of BM harvested post-mortem. Also shown is analysis of a lymph node tumor found in one BCRABL Y177F mouse. Mac-1Gr-1 staining for myeloid cells, B220CD19 staining for B cells, Thy1.2CD3ϵ staining for T cells, and c-Kit staining for immature cells.
Frontiers of Medicine,2013,7(4), Doi: /s