1. Synthesis and catabolism of serotonin and the catecholamines
Synthesis and catabolism of serotonin and the catecholamines. Trp, tryptophan; 5HTP, 5-hydroxytryptophan; 5HIAA, 5-hydroxyindoleacetic acid; BH , tetrahydrobiopterin; qBH2, quinonoid dihydrobiopterin; Tyr, tyrosine; 3OMD, 3-O-methyldopa; DOPAC, dihydroxyphenylacetic acid; 3MT, 3-methoxytyramine; HVA, homovanillic acid; DHPG, dihydroxyphenylglycol; MHPG, 3-methoxy-4-hydroxyphenylglycol; VMA, vanillylmandelic acid; NMN, normetanephrine; MN, metanephrine; DHPR, dihydropteridine reductase; TPH, tryptophan hydroxylase; TH, tyrosine hydroxylase; AADC, aromatic L-amino acid decarboxylase; COMT, catechol-O-methyltransferase; MAO, monoamine oxidase; SNA, serotonin N-acetylase; HOMT, hydroxyindole-O-methyltransferase; ALD, aldehyde dehydrogenase; DβH, dopamine β-hydroxylase; AR, aldehyde reductase; PNMT, phenylethanolamine-N-methyltransferase. The major cerebrospinal fluid (CSF) markers used to diagnose defects are boxed. Enzymes with known inherited defects are circled.
Source: Disorders of Tetrahydrobiopterin and Related Biogenic Amines, The Online Metabolic and Molecular Bases of Inherited Disease
Citation: Valle D, Beaudet AL, Vogelstein B, Kinzler KW, Antonarakis SE, Ballabio A, Gibson K, Mitchell G. The Online Metabolic and Molecular Bases of Inherited Disease; 2014 Available at: Accessed: December 21, 2017
Copyright © 2017 McGraw-Hill Education. All rights reserved