1. Group on Neural Issues

2. Outline Key gaps in knowledge Barriers and opportunities
Methodological needs
Research priorities for the future

3. 1. Key gaps in knowledge

4. 1. Key gaps in knowledge Biological changes with exercise in humans
Can these changes provide biomarkers
Determinants of rate of recovery
Characteristics of effective exercise
Gender, race, culture-dependent efficacy
How best to promote brain health
Education? Incentives? Penalties?
Special requirements for people at high risk
Education of legislators, policy makers

5. 2. Barriers and opportunities
a. Barriers

6. 2. Barriers and opportunities
a. Barriers
Finer distinctions
Measurements of deficits
Design of Rx
“Reverse translation:” Bedside to bench
Need to expand considerations of mood (depression is only one facet)

7. 2. Barriers and opportunities
b. Opportunities

8. 2. Barriers and opportunities
b. Opportunities
Large clinical trials
Data sets
Ongoing or planned
Professional meetings (provide education)

9. 3. Methodological needs

10. 3. Methodological needs How to influence behavior? (and when?)
More precise Rx
Tracking compliance
Better scales to measure
Prediction of responders to given treatment
Can genomics help?
Personality traits
Impact

11. 4. Research priorities

12. 4. Research priorities What is impact of interventions, combos
Neurobiological
Clinical
How large is the problem?
Personal and Societal
What are the risk factors?
Identification of biomarkers (risk, impact)
Make better use of ongoing trials
Why low compliance?
How to promote behavior for healthy brain?