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A new approach to chromosomal abnormalities in sperm from patients with oligoasthenoteratozoospermia: detection of double aneuploidy in addition to single.

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Presentation on theme: "A new approach to chromosomal abnormalities in sperm from patients with oligoasthenoteratozoospermia: detection of double aneuploidy in addition to single."— Presentation transcript:

1 A new approach to chromosomal abnormalities in sperm from patients with oligoasthenoteratozoospermia: detection of double aneuploidy in addition to single aneuploidy and diploidy by five-color fluorescence in situ hybridization using one probe set  Hatice Gul Durakbasi-Dursun, Ph.D., Ayse Gul Zamani, M.D.,Ph.D., Ruhusen Kutlu, M.D., Hüseyin Görkemli, M.D., Muhterem Bahce, M.D.,Ph.D., Aynur Acar, Ph.D.  Fertility and Sterility  Volume 89, Issue 6, Pages (June 2008) DOI: /j.fertnstert Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

2 Figure 1 The comparison of disomy frequencies (%) in patients with OAT and controls for examined chromosomes. Values are expressed as average ± SEM for controls and patients with OAT. ∗P<.001 represents the significance level between controls and patients with OAT. OAT = oligoasthenoteratozoospermia. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

3 Figure 2 The comparison of nullisomy frequencies (%) in patients with OAT and controls for examined chromosomes. Values are expressed as average ± SEM for controls and patients with OAT. ∗P<.001 represents the significance level between controls and patients with OAT. OAT = oligoasthenoteratozoospermia; SC = sex chromosome. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

4 Figure 3 The comparison of diploidy, single aneuploidy, double aneuploidy, and total aneuploidy frequencies (%) in patients with OAT and controls for examined chromosomes. Values are expressed as average ± SEM for controls and patients with OAT. ∗P<.001 represents the significance level between controls and patients with OAT. OAT = oligoasthenoteratozoospermia; D = diploidy; SA = single aneuploidy; DA = double aneuploidy; TA = total aneuploidy (single aneuploidy + double aneuploidy). Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions


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