1. Infectious Mononucleosis Tests
Lesson 4-2
Infectious Mononucleosis Tests

2. Infectious Mononucleosis (IM)
Contagious
Mostly in 15–25 year-olds
Caused by Epstein-Barr virus (EBV)
Worldwide
Latent
Transmission
Link to other conditions

3. Diagnosis of IM Clinical symptoms Fever Sore throat Fatigue
Lymphadenopathy
Hepatosplenomegaly

4. Diagnosis of IM Hematological findings Immunological findings
Lymphocytosis
Atypical lymphs
Immunological findings
Rapid tests

5. Immunological Findings in IM
Heterophile antibodies
IgM class
Detectable 7–10 days after onset
Rapid immunological tests detect heterophile antibodies

6. Rapid Tests for IM Immunochromatographic assays Principle Rapid
Simple to perform
Principle
Adaptation of Davidsohn differential test
Tests self-contained in cassette

7. Performing Rapid Test for IM
Safety precautions
Quality assessment
Specimen collection
Procedure

8. Performing Rapid Test for IM

9. Interpreting Results See Table 4-6 Internal and external controls
Patient results
Clinical significance of EBV
infection
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