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The science: accuracy, reliability and interpretation. Andrew P. Read

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1 The science: accuracy, reliability and interpretation. Andrew P. Read
The science: accuracy, reliability and interpretation Andrew P. Read Professor of Human Genetics, University of Manchester

2 Fingerprinting A cornerstone of forensic crime scene investigation
A fingerprint ‘match’ is a matter of expert opinion There have been several criminal cases where fingerprint evidence has proven flawed (rare), e.g. Brandon Mayfield

3 DNA profiling Sample obtained from suspect, volunteer or crime scene
Used to create DNA profile, which is entered onto DNA Database ‘Biological sample’ is also stored indefinitely

4 Using DNA evidence Profile on database: 13,14; 29,30; 16,18; 16,17; 15,18; 11,12; 18,19; 14; 6,3.5; 16,18; X,Y. Each profile is one in a billion Crime scene or subject DNA can be checked against profiles on Database A match with a complete profile provides powerful evidence DNA evidence alone is not sufficient to prove guilt – other evidence needed

5 The interpretation of DNA
Complete profiles provide robust and reliable evidence Problems with: Mixed samples Partial profiles Contamination Very small samples DNA can only confirm presence at a crime scene

6 Other uses of DNA Familial searching Ethnic inferencing Surnames ?
DNA ‘photofits’ ?? Health-related information ??? Profile on database: 13,14; 29,30; 16,18; ,17; 15,18; 11,12; 18,19; 14; 6,3.5; 16,18; X,Y.


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