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Systematic review and meta-analysis on the nonsurgical treatment of chronic periodontitis by means of scaling and root planing with or without adjuncts Christopher J. Smiley, DDS, Sharon L. Tracy, PhD, Elliot Abt, DDS, MSc, MS, Bryan S. Michalowicz, DDS, Mike T. John, Dr med dent, PhD, MPH, John Gunsolley, DDS, MS, Charles M. Cobb, DDS, PhD, Jeffrey Rossmann, DDS, MS, Stephen K. Harrel, DDS, Jane L. Forrest, EdD, Philippe P. Hujoel, DDS, MSD, MS, PhD, Kirk W. Noraian, DDS, MS, MBA, Henry Greenwell, DMD, MSD, Julie Frantsve- Hawley, PhD, Cameron Estrich, MPH, Nicholas Hanson, MPH The Journal of the American Dental Association Volume 146, Issue 7, Pages e5 (July 2015) DOI: /j.adaj Copyright © 2015 American Dental Association Terms and Conditions
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Figure 1 Flow diagram of literature search and screening process.
The Journal of the American Dental Association , e5DOI: ( /j.adaj ) Copyright © 2015 American Dental Association Terms and Conditions
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Figure 2 Risk of bias as a percentage of included studies for scaling and root planing according to domain. The Journal of the American Dental Association , e5DOI: ( /j.adaj ) Copyright © 2015 American Dental Association Terms and Conditions
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Figure 3 Meta-analysis of studies on scaling and root planing (SRP) grouped according to study design; mean difference in clinical attachment level is in millimeters. Weighted percentages may not add up due to rounding and significant figures reported. CI: Confidence interval. df: Degrees of freedom. IV, Inverse-variance: I. SE: Standard error. The Journal of the American Dental Association , e5DOI: ( /j.adaj ) Copyright © 2015 American Dental Association Terms and Conditions
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Figure 4 Meta-analysis of studies on scaling and root planing (SRP) plus subantimicrobial-dose doxycycline (SDD) versus SRP alone; mean difference in clinical attachment level is in millimeters. CI: Confidence interval. df: Degrees of freedom. IV: Inverse-variance. SE: Standard error. The Journal of the American Dental Association , e5DOI: ( /j.adaj ) Copyright © 2015 American Dental Association Terms and Conditions
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Figure 5 Meta-analysis of studies on scaling and root planing (SRP) plus systemic antimicrobials versus SRP alone, subgrouped according to antimicrobial type; mean difference in clinical attachment level is in millimeters. Weighted percentages may not add up due to rounding and significant figures reported. CI: Confidence interval. df: Degrees of freedom. IV: Inverse-variance. mg: Milligrams. SE: Standard error. The Journal of the American Dental Association , e5DOI: ( /j.adaj ) Copyright © 2015 American Dental Association Terms and Conditions
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Figure 6 Meta-analysis of studies on scaling and root planing (SRP) plus chlorhexidine chips versus SRP alone, grouped according to study design; mean difference in clinical attachment level is in millimeters. Weighted percentages may not add up due to rounding and significant figures reported. CI: Confidence interval. df: Degrees of freedom. IV: Inverse-variance. SE: Standard error. The Journal of the American Dental Association , e5DOI: ( /j.adaj ) Copyright © 2015 American Dental Association Terms and Conditions
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Figure 7 Meta-analysis of studies on scaling and root planing (SRP) plus doxycycline hyclate (DH) gel versus SRP alone, subgrouped according to study design; mean difference in clinical attachment level is in millimeters. CI: Confidence interval. df: Degrees of freedom. IV: Inverse-variance. SE: Standard error. The Journal of the American Dental Association , e5DOI: ( /j.adaj ) Copyright © 2015 American Dental Association Terms and Conditions
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Figure 8 Meta-analysis of studies on scaling and root planing (SRP) plus minocycline microspheres (MM) versus SRP alone, subgrouped according to study design; mean difference in clinical attachment level is in millimeters. Weighted percentages may not add up due to rounding and significant figures reported. CI: Confidence interval. df: Degrees of freedom. IV: Inverse-variance. SE: Standard error. The Journal of the American Dental Association , e5DOI: ( /j.adaj ) Copyright © 2015 American Dental Association Terms and Conditions
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Figure 9 Meta-analysis of studies on scaling and root planing (SRP) plus photodynamic therapy (PDT) diode laser versus SRP alone, grouped according to study design; mean difference in clinical attachment level is in millimeters. Weighted percentages may not add up due to rounding and significant figures reported. CI: Confidence interval. df: Degrees of freedom. IV: Inverse-variance. SE: Standard error. The Journal of the American Dental Association , e5DOI: ( /j.adaj ) Copyright © 2015 American Dental Association Terms and Conditions
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Figure 10 Meta-analysis of studies on scaling and root planing (SRP) plus nonphotodynamic therapy (non-PDT) laser versus SRP alone; mean difference in clinical attachment level is in millimeters. Weighted percentages may not add up due to rounding and significant figures reported. CI: Confidence interval. df: Degrees of freedom. IV: Inverse-variance. SE: Standard error. The Journal of the American Dental Association , e5DOI: ( /j.adaj ) Copyright © 2015 American Dental Association Terms and Conditions
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Figure 11 Meta-analysis of studies on scaling and root planing (SRP) plus neodymium:yttrium-aluminum-garnet (Nd:YAG) laser versus SRP alone; mean difference in clinical attachment level is in millimeters. CI: Confidence interval. df: Degrees of freedom. IV: Inverse-variance. SE: Standard error. The Journal of the American Dental Association , e5DOI: ( /j.adaj ) Copyright © 2015 American Dental Association Terms and Conditions
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Figure 12 Meta-analysis of studies on scaling and root planing (SRP) plus erbium laser versus SRP alone; mean difference in clinical attachment level is in millimeters. Weighted percentages may not add up due to rounding and significant figures reported. CI: Confidence interval. df: Degrees of freedom. IV: Inverse-variance. SE: Standard error. The Journal of the American Dental Association , e5DOI: ( /j.adaj ) Copyright © 2015 American Dental Association Terms and Conditions
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eFigure 1 Risk of bias as a percentage of included studies for scaling and root planing plus subantimicrobial-dose doxycycline, according to domain. The Journal of the American Dental Association , e5DOI: ( /j.adaj ) Copyright © 2015 American Dental Association Terms and Conditions
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eFigure 2 Risk of bias as a percentage of included studies for scaling and root planing plus systemic antimicrobials, according to domain. The Journal of the American Dental Association , e5DOI: ( /j.adaj ) Copyright © 2015 American Dental Association Terms and Conditions
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eFigure 3 Risk of bias as a percentage of included studies for scaling and root planing plus chlorhexidine chips, according to domain. The Journal of the American Dental Association , e5DOI: ( /j.adaj ) Copyright © 2015 American Dental Association Terms and Conditions
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eFigure 4 Risk of bias as a percentage of included studies for scaling and root planing plus doxycycline hyclate gel, according to domain. There were 3 studies. The Journal of the American Dental Association , e5DOI: ( /j.adaj ) Copyright © 2015 American Dental Association Terms and Conditions
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eFigure 5 Risk of bias as a percentage of 4 included studies for scaling and root planing plus minocycline microspheres, according to domain. The Journal of the American Dental Association , e5DOI: ( /j.adaj ) Copyright © 2015 American Dental Association Terms and Conditions
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eFigure 6 Risk of bias as a percentage of included studies for scaling and root planing plus a photodynamic therapy diode laser, according to domain. The Journal of the American Dental Association , e5DOI: ( /j.adaj ) Copyright © 2015 American Dental Association Terms and Conditions
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eFigure 7 Risk of bias as a percentage of included studies for scaling and root planing plus a non-photodynamic therapy diode laser, according to domain. The Journal of the American Dental Association , e5DOI: ( /j.adaj ) Copyright © 2015 American Dental Association Terms and Conditions
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eFigure 8 Risk of bias as a percentage of included studies for scaling and root planing plus a neodymium:yttrium-aluminum-garnet laser, according to domain. The Journal of the American Dental Association , e5DOI: ( /j.adaj ) Copyright © 2015 American Dental Association Terms and Conditions
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eFigure 9 Risk of bias as a percentage of included studies for scaling and root planing plus an erbium laser, according to domain. The Journal of the American Dental Association , e5DOI: ( /j.adaj ) Copyright © 2015 American Dental Association Terms and Conditions
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