1. Supplemental table. Protocol for side effect management of AFA
Diarrhea
Skin rash/Paronychia
Stomatitis
Grade <1 (there is no symptom)
Bifidobacterium antiflatulent（LAC-B® Granular Powder N） 1g　po t.i.d.
Heparinoid ointment (Hirudoid® Soft Ointment 0.3%) 50g/week for trunk and hand, foot.　
Pyridoxal phosphate (PYDOXAL® 10mg)　10mg　po t.i.d.
Azulene sulfonate sodium gargle (Azunol® Gargle liquid 4％) q.i.d.
Azulene sulfonate sodium, glutamine (MARZULENE® S COMBINATION GRANULES)　2g　po t.i.d.
Grade 1 or 2
Loperamide hydrochloride (LOPEMIN® capsules 1mg) 　2mg po　
Take it every two hours until diarrhea is relieved.　
If diarrhea is not improved within 48 hours, AFA is stopped
Heparinoid ointment (Hirudoid® Soft Ointment 0.3%) 25g + hydrocortisone butyrate ointment (LOCOID® ointment 0.1%) 15g mixture, twice a day for face.
Heparinoid ointment (Hirudoid® Soft Ointment 0.3%) 75g +
betamethasone butyrate propionate ointment (ANTEBATE® ointment 0.05%) 25g　mixture, twice a day for trunk.
Minocycline hydrochloride (MINOMYCIN® CAPSULES 100mg) s.i.d.
Clobetasol propionate ointment (Dermovate® Ointment) 5g, twice a day for paronychia．
PAG solution (in-house prescription)※
10mL po q.i.d.　
※PAG solution was a mixture of 5% sodium alginate (Alroid G oral solution) 200mL and polaprezinc (Promac® D tablets 75) 10 tablets.
Grade ≧3
The AFA administration is stopped until a symptom is improved. Electrolyte infusion is administered. If a symptom is improved, reduce dose AFA is readministrated.
The AFA administration is stopped until a symptom is improved. If a symptom is improved, reduce dose AFA is readministrated.
The AFA administration is stopped until a symptom is improved.
If oral intake is insufficient, the peripheral parenteral nutrition is administered. If a symptom is improved, reduce dose AFA is readministrated.