1. Aged Mice are More Resistant to Influenza Virus Infection due to Reduced Inflammation and Lung Pathology
Lu Jiao 1, 2 ;Duan Xuefeng 1 ;Zhao Wenming 1 ;Wang Jing 1, 2 ;Wang Haoyu 3, 1 ;Zhou Kai 1 ;Fang Min 1, 4 ;
1 CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing , China. ; 2 University of Chinese Academy of Sciences, Beijing, China ; 3 Institute of Health Sciences, Anhui University, Hefei, China ; 4 International College, University of Chinese Academy of Sciences, Beijing, China ;
Figure 3. Neutrophils and DC cell percentage increased in the young mice but not in the aged mice after infection. Young and aged B6 mice were infected i.n. with 1#cod#x000D7;10 3 PFU PR8 virus. A Gating strategy of cell populations. The cells were firstly gated on myeloid cells. Alveolar macrophages were CD11b lowmid CD11c + , we also confirmed that all the cells were F480 + ; DC cells were CD11b high CD11c + ; neutrophils were CD11b + CD11c - Gr1 + . B Percentage of the indicated cells before and after IAV infection. Data are representative of two similar experiments with 3-5 mice per group in each experiment. Data points indicate means #cod#x000B1; SD. #cod#x0002A; p , #cod#x0002A;#cod#x0002A; p
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