1. Biomedical Knowledge Navigation: Interactive tools for clinical and research insight
Harry Hochheiser
Assistant Professor
Department of Biomedical Informatics
Intelligent Systems Program
University of Pittsburgh
Center for Causal Discovery (
Biomedical Informatics Training Program

2. The data interpretation challenge
Clinicians and translational researchers are swamped with data
Lab measurements, meds, clinical notes, imaging data in EMRs
Genomics, microbiome, expression profiles, phenotypes..
Experts need tools that
Get them closer to the data
Facilitate exploration and hypothesis generation
Visual analytics to support knowledge work as an ongoing process
Goal: Develop innovative tools that reduce the gap between data and insight
Approach
Qualitative investigation of problem domains and user needs and challenges
Iterative prototyping and refining of ideas
Mixed-methods (qualitative and quantitative) evaluations

3. Clinical and Translational Applications
Navigation and exploration tools for data repositories Developmental Biology, 355(2), Hochheiser, et al.
Collaborator identification in research social networks
J. Medical Internet Research 16(11).e244,2014. Borromeo, et al.
Exploration of genotype-phenotype relationships Mammalian Genome Haendel, et al.
Interactive review of natural language processing results from clinical notes TextVis 2015, Trivedi, et al.

4. Ongoing Support
The Monarch Initiative: Linking diseases to model organism resources NIH OD: R24OD011883, R24OD S1
Interactive Search and Review of Clinical Records with Multilayered Semantic Annotation NLM: R01LM
Sarcoidosis and A1AT Genomics & Informatics Center NHLBI: U01HL112707, U01 HL A1S1
Addressing gaps in clinically useful evidence on drug-drug interactions NLM: R01LM011838
Cancer Deep Phenotype Extraction from Electronic Medical Records NCI: U24CA184407
Center for Causal Modeling and Discovery of Biomedical Knowledge from Big Data NHGRI: U54HG008540
Quantifying Electronic Medical Records Usability to Improve Clinical Workflow AHRQ: R01HS021290
Human Genomics Analysis Interface For FaceBase 2. NIDCR: U01DE024425