Presentation is loading. Please wait.

Presentation is loading. Please wait.

Epistasis.

Similar presentations


Presentation on theme: "Epistasis."— Presentation transcript:

1 Epistasis

2 Definition Epistasis is a form of gene interaction in which one gene masks the phenotypic expression of another. There are no new phenotypes produced by this type of gene interaction.

3 Epistatic versus Hypostatic
The alleles that are masking the effect are called epistatic alleles. The alleles whose effect is being masked are called the hypostatic alleles.

4 How do we solve epistatic problems?
We are dealing with polygenic traits as in the previous section, however we now have one pair of alleles masking the other. This means we will still be using dihybrid crosses!

5 Recessive or Dominant? Epistasis can be described as either recessive epistasis or dominant epistasis. Let’s look at an example of recessive epistasis….

6 Labrador Retrievers Fur color in Labrador Retrievers is controlled by two separate genes. Fur color is a polygenic trait! Gene 1: Represented by B : Controls color Gene 2: Represented by E : Controls expression of B

7 Labrador Retrievers If a Labrador retriever has a dominant B allele, they will have black fur. If they have two recessive alleles (bb) they will have brown fur.

8 Labrador Retrievers If a retriever receives at least one dominant “E” allele, they will remain the color that the “B” allele coded for. Either black of brown However, if a dog receives a pair of homozygous recessive “e” alleles, they will be golden regardless of their “B” alleles!

9 Labrador Retrievers BBEE and BbEe --> Black retrievers
bbEE and bbEe --> Brown retrievers BBee, Bbee, or bbee --> Golden retrievers

10 Try this cross… You have decided to cross your golden retriever (bbee) with the neighbor’s chocolate retriever (bbEe). What color pups will they have?

11 bbee x bbEe FOIL: be FOIL: bE or be
Genotypes of F1 generation: bbEe and bbee Pups phenotypes: Brown and golden

12 Dominant Epistasis Let’s have a look at dominant epistasis…
Squash fruit color is controlled by two genes. Gene 1 is represented by a W Gene 2 is represented by a G

13 Squash Fruit Color Genotypes and Phenotypes: W-/G- white W-/gg white
ww/G green ww/gg yellow

14 Squash Fruit Color Which allele is epistatic in squash color?
How do you know? The dominant W allele is epistasis Because every time a dominant W allele shows up in a squash genotype, the squash fruit color is white.

15 Try this cross…. Cross a green squash (wwGg) with a white squash (Wwgg). What color are the offspring?

16 Wwgg x wwGg FOIL: Wg or wg FOIL: wG or wg F1 generation genotypes:
Phenotypes:

17 EXPRESSION OF ABO Genotype present phenotype H_ IAIA, H_ IAi Yes A
H_ IBIB, H_ IBi Yes B H_ IAIB Yes AB H_ ii Yes O hh IAIA, hh IAi, hh IBIB, No O hh IBi, hh IAIB, and hh ii In this example, the alleles at the ABO locus are hypostatic to the recessive h allele.

18 Duplicate recessive epistasis
Duplicate recessive epistasis, in which two recessive alleles at either of two loci are capable of suppressing a phenotype. This type of epistasis is illustrated by albinism in snails.

19 dominant alleles at both loci (A_ B_) produce pigmented snails; any other genotype produces albino snails: P aa BB × AA bb Albino Albino F1 Aa Bb Pigmented Intercross F2 9/16 A_ B_ pigmented 3/16 aa B_ albino 3/16 A_ bb albino 1/16 aa bb albino


Download ppt "Epistasis."

Similar presentations


Ads by Google