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Med Chem Tutoring for Anticoagulants, Antiplatelets, and Thrombolytics
By Alaina Darby
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Anticoagulants
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Which of the following is not an anticoagulant? Dabigatran Warfarin
Aspirin Heparin C
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Which of the following is true of heparin? Strong base Weak base
Weak acid Strong acid D
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Which of the following makes heparin acidic? Sulfate groups
Alcohol groups Amide groups Peptide bonds A
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Which of the following is not involved in the intrinsic pathway? XII
VII II C
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Which of the following does not have a role in both the intrinsic and extrinsic pathways?
II VII X C
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Which of the following is activated by heparin? Thrombin
Antithrombin III Prothrombin Fibrin B Which inactivates thrombin
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Which of the following is not true of heparin? Is used after MI
Orally effective Short DOA Causes HIT B
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Which of the following is a risk factor for developing a DVT?
Phlebitis Pulmonary embolism Lower extremity surgery Myocardial infarction C A and B are things that can happen due to a DVT
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What is the primary mechanism by which protamine sulfate works?
Binds to ATIII Has coagulant activity Has anticoagulant activity Strongly basic peptide D
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Which of the following is not an advantage of LMWH over heparin?
Longer half life Less thrombocytopenia Higher bioavailability Can be given orally D (but can be given at home IM!)
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Which of the following selectively inhibits Factor Xa but has no effect on thrombin?
Fondaparinux Enoxaparin Dalteparin Tinzaparin A
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Which of the following is a polypeptide? Heparin Enoxaparin
Fondaparinux Desirudin D
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Which amino acid sequence binds the thrombin active site?
D-Phe-Pro-Arg-Pro D-Pro-Phe-Arg-Pro D-Pro-Arg-Pro-Phe D-Pro-Arg-Phe-Pro A I think there may have been a question comparing the argatroban structure to the peptide sequence… know that.
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Which of the following can be used for a patient that has had HIT?
Heparin Argatroban Enoxaparin Fondaparinux B
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Which of the following is a zwitterion? Argatroban Dabigatran
Rivaroxaban Epixaban B
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Which of the following is a double prodrug? Argatroban Dabigatran
Rivaroxaban Epixaban B
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Which of the following is warfarin? A. B. C. D.
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Which of the following is true of the properties of warfarin?
Weak acid; (S) isomer is most active Weak acid; (R) isomer is most active Weak base; (S) isomer is most active Weak base; (R) isomer is most active A
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Which of the following should be done for major warfarin overdoses?
Drug withdrawal Give vitamin K Give Menadione sodium bisulfite B&C All of the above E
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Which of the following enhances warfarin activity? Vitamin K
Griseofulvin Metronidazole Phenobarbital C
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Phenylbutazole: inhibit CYPs Antibiotics: kill microbes in GIT
Which of the following enhancers of warfarin effects is not properly paired to its mechanism? Phenylbutazole: inhibit CYPs Antibiotics: kill microbes in GIT Chloramphenicol: inhibit CYPs Anabolic steroids: unknown A
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Which of the following can only maintain blood up to 21 days?
Anticoagulant sodium citrate Anticoagulant citrate dextrose Anticoagulant citrate phosphate dextrose Anticoagulant citrate phosphate dextrose adenine B
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Antiplatelets
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Platelets adhere to damaged subendothelial tissues
Which of the following is not included in phase I platelet aggregation? Platelets adhere to damaged subendothelial tissues Platelets don’t adhere to undamaged endothelial tissue Hemostasis is induced Release chemical mediators from platelets D
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Which of the following is not true of dipyridamole?
Induces vasodilation Increases levels of cAMP Decreases adenosine Inhibits PDE3 C
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Which of the following should not be used as sole therapy? Warfarin
Enoxaparin Aspirin Dipyridamole D
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Into which of the following is prasugrel classified? PDE3 inhibitor
COX inhibitor ADP inhibitor Glycoprotein IIb/IIIa receptor inhibitor C
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Into which of the following is dipyridamole classified? PDE3 inhibitor
COX inhibitor ADP inhibitor Glycoprotein IIb/IIIa receptor inhibitor A
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Into which of the following is eptifibatide classified? PDE3 inhibitor
COX inhibitor ADP inhibitor Glycoprotein IIb/IIIa receptor inhibitor D
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Into which of the following is aspirin classified? PDE3 inhibitor
COX inhibitor ADP inhibitor Glycoprotein IIb/IIIa receptor inhibitor B
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Which of the following is a prodrug that must be activated by CYP2C19?
Ticlopidine Clopidogrel Prasugrel B
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Fibrinolytics
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For which of the following are fibrinolytics not used? Acute MI
Deep vein thrombosis Pulmonary embolism Thrombotic stroke B
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Which of the following is the most immunogenic? Streptokinase
Alteplase Reteplase Tenecteplase A
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Which of the following has the highest specificity for fibrin?
Streptokinase Alteplase Reteplase Tenecteplase D
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Which of the following is not produced using recombinant DNA technology?
Streptokinase Alteplase Reteplase Tenecteplase A
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