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Does Acute Organ Dysfunction Predict Patient-Centered Outcomes?

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Presentation on theme: "Does Acute Organ Dysfunction Predict Patient-Centered Outcomes?"— Presentation transcript:

1 Does Acute Organ Dysfunction Predict Patient-Centered Outcomes?
Gilles Clermont, MD, MSc, Derek C. Angus, MD, MPH, FCCP, Walter T. Linde-Zwirble, Martin F. Griffin, MS, Michael J. Fine, MD, Michael R. Pinsky, MD, FCCP  CHEST  Volume 121, Issue 6, Pages (June 2002) DOI: /chest Copyright © 2002 The American College of Chest Physicians Terms and Conditions

2 Figure 1 Kaplan-Meier survival analysis by degree of AOD. Among patients surviving at least 30 days, the cohort with acute dysfunction in more than one organ system had significantly worse survival times (p < 0.05 [log rank test]). CHEST  , DOI: ( /chest ) Copyright © 2002 The American College of Chest Physicians Terms and Conditions

3 Figure 2 SF-36 summary scores before the onset of CAP, at 30 days, and at 90 days reported by degree of AOD. Top, A: Physical component summary scores. Bottom, B: mental component summary scores. Physical component summary scores were different from baseline at 30 days (*p < 0.05 [paired t test]) and did not completely recover by 90 days. Mental component summary scores recovered to baseline levels by 30 and 90 days. There was a trend toward a difference across subgroups with different degrees of organ dysfunction at 90 days (p = 0.04 [ANOVA]). Organ dysfunction = AOD. CHEST  , DOI: ( /chest ) Copyright © 2002 The American College of Chest Physicians Terms and Conditions

4 Figure 3 Kaplan-Meier analysis of the return to usual activities by degree of organ dysfunction. Information on the return to usual activities was available for two thirds of the patients known to be alive at 90 days. Patients with a greater degree of organ dysfunction resumed usual activities later (p < [log rank test]). Because of the high rate of censoring and the potential in bias as to the rate of return to activities in those censored, the absolute rates of return at 90 days cannot be estimated with confidence. CHEST  , DOI: ( /chest ) Copyright © 2002 The American College of Chest Physicians Terms and Conditions


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