1. Nano Cost Nano Patterned Template for
Surface Enhanced Raman Scattering
H.-C. Hou, J. Kim, K. Kanakamedla, S Basu,
T. Daniels-Race,* and M. Feldman H
Division of Electrical and Computer Engineering
*LSU Center for Computation & Technology
Louisiana State University
Baton Rouge, LA 70803
Work supported in part by the NIH

2. Raman Scattering

3. Raman Spectrometer

4. Surface Enhancement Raman Spectrometer (SERS)
(Rhodamine 6G in DI Water)

5. Aluminum Foil Substrates
Sample Size: 1 cm x 1 cm
Sample Cost: cents
Front Side: Smooth
Scatters light in 1 direction
Back Side: Dull
Scatters light in 2 directions
Application: Conventional

6. Rhodamine 6G Spectra from Aluminum Foil
Front
Front
Front
Back
Back
Back
Not Etched
Etched
Etched and Stirred

7. 99.99% Pure Aluminum Pellet Not Etched Etched Raman Signal

8. Shop Grade Aluminum Sample
Raman Signal
Raman Signal
Non Etched
Etched

9. Aluminum Substrate All Aluminum Works the Same More or less
Etching helps
Foil
Pure aluminum
Shop grade aluminum

10. 20 nm of Gold Sputtered on Aluminum Foil
20,000
10,000
Raman Signal

11. Sketch of Sputtering Chamber

12. Position in Sputtering Chamber

13. Position in Sputtering Chamber

14. Signal from Low to High Concentrations
Au on Aluminum Foil
Intensity (A. U. )
Concentration - μM

15. Gold Further Enhances Aluminum Signal
A Little Gold Goes a Long Way
(ancient saying)
Especially at edge of sputtering chamber

16. Clinical Applications
Conventional
Remote Probe

17. Conventional vs Probe

18. Remote Probe

19. Couple GRIN Lens to Spectrometer

20. Fabrication of Probe
(or GRIN Lens)

21. Raman Spectra Conventional Probe Intensity (A.U.) Intensity (A.U.)
Raman Shift (cm-1)
Raman Shift (cm-1)
Conventional
Probe 21

22. Raman Signal Through Epoxy and Gold

23. Shape of Exposed Gold May Changeu m i E x y

24. Probe in Gelatin Block- 1.1 meter from Spectrometer

25. Spectrum – 1mM Rhodamine in Gelatin

26. Signal in Cell from Low to High Concentrations
Au on Epoxy Probe
Intensity (A. U. )
Concentration - μM

27. In Situ Application of Probe

28. Biologic Results After Vardaki et al. Our Chicken Results
Chicken Bone
After Vardaki et al.
University of Patras, 2013
Our Chicken Results

29. Thank you!

30. Raman Signal vs. Angle of Incidence
Not Etched Pellet

32. Au on Glass

33. AFM and SEM Au on Glass

34. AFM images of Aluminum (F)
Non Etched
Etched

35. AFM images of Aluminum (B)
Non Etched
Etched

36. AFM Au on etched Al (F)

37. AFM and SEM Au on etched and stirred Al (F)
Scale Bar 300nm 1= 30nm
1.3 um x 1.3 um Scale 25nm 37

38. AFM Au on Epoxy (Stirred and Etched Al Removed)