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VI World Cornea Congress, Boston April 7-9, 2010.

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Presentation on theme: "VI World Cornea Congress, Boston April 7-9, 2010."— Presentation transcript:

1 VI World Cornea Congress, Boston April 7-9, 2010.
BIODEGRADABLE COLLAGEN MATRIX IMPLANT: NEW TREATMENT FOR PTERYGIUM. Nerea SÁENZ MADRAZO, MD., PhD.; B. SARMIENTO, MD., PhD.; T. COLÁS, MD.; A. JULVE, MD.; M.J. ALONSO, MD.; R. SEOANE, MD. Hospital 12 de Octubre (Madrid, Spain). Authors have no financial interest. 1

2 Ophthalmology Department Hospital 12 de Octubre
PURPOSE PURPOSE MATERIALS RESULTS CONCLUSIONS PURPOSE To evaluate the effectiveness and safety of the use of a biodegradable collagen matrix (Oculusgen®) in pterygium surgery In Spain, immigration from countries located at the ‘pterygium belt’ is increasing. It explains the raise of aggressive pterygium prevalence in young population what constitutes a challenge for anterior segment surgeons. Ophthalmology Department Hospital 12 de Octubre 2

3 Ophthalmology Department Hospital 12 de Octubre
PURPOSE PURPOSE MATERIALS RESULTS CONCLUSIONS What is Oculusgen®? It is a collagen matrix implant, a biodegradable scaffold, which can induce a regenerative non-scarring wound healing process without the use of medicine. This collagen implant improves the remodeling of the regenerating tissue and prevents scar formation. The role of Oculusgen® in preventing pterygium recurrent: Localize the bare scleral wound healing. Reduce wound contraction. Keep the area of bare sclera from ingrowth of the new fibrovascular tissue. Ophthalmology Department Hospital 12 de Octubre 3

4 Ophthalmology Department Hospital 12 de Octubre
PURPOSE MATERIALS MATERIALS RESULTS CONCLUSIONS MATERIALS A prospective and non-randomized study was performed during 2009. It includes 20 eyes of 20 patients. They were treated with a biodegradable collagen matrix implant (Oculusgen®) after pterygium resection (simple excision). Patients were followed for at least 3 months. Ophthalmology Department Hospital 12 de Octubre 4

5 Ophthalmology Department Hospital 12 de Octubre
PURPOSE RESULTS MATERIALS RESULTS CONCLUSIONS General description Of 20 patients, 11 were men (55%) and 9 women (45%). Mean age was / years (range: years). 60% were primary pterygium (12/20), 40% were recurrent ones (37.5% of them having previously recurred twice) 95% were nasally located. 6 patients (30%) had both eyes affected. 75% (15/20) of patients were from South American countries. Ophthalmology Department Hospital 12 de Octubre 5

6 Ophthalmology Department Hospital 12 de Octubre
PURPOSE RESULTS MATERIALS RESULTS CONCLUSIONS Surgical results Pterygium recurrence rate was 5% There were no surgical complications neither adverse effects. Ophthalmology Department Hospital 12 de Octubre 6

7 Ophthalmology Department Hospital 12 de Octubre
PURPOSE RESULTS MATERIALS RESULTS CONCLUSIONS Surgical results Pterygium both eyes, primary pt. Follow-up time: 8 months. Pictures: Postop day, 8 months after. Ophthalmology Department Hospital 12 de Octubre 7

8 Ophthalmology Department Hospital 12 de Octubre
PURPOSE RESULTS MATERIALS RESULTS CONCLUSIONS Surgical results Pterygium right eye, recurrent pt. Follow-up time: 9 months. Pictures: Postop day, 2 months after, 9 months after. Ophthalmology Department Hospital 12 de Octubre 8

9 Ophthalmology Department Hospital 12 de Octubre
PURPOSE RESULTS MATERIALS RESULTS CONCLUSIONS Surgical results Pterygium right eye, recurrent pt. Follow-up time: 4 months. Pictures: Postop day, 3 weeks after, 4 months after. Ophthalmology Department Hospital 12 de Octubre 9

10 PTERYGIUM SURGICAL OPTIONS
PURPOSE CONCLUSIONS MATERIALS RESULTS CONCLUSIONS PTERYGIUM SURGICAL OPTIONS Simple excision (recurrence rates 30-80%) (+ beta irradiation, +Mitomycin C) Amniotic membrane transplantation (1) Conjunctival autograft (recurrence rates 2-39%) (2,3) Suture (Vycril 8-0) Fibrin glue (Tissucol®) Biodegradable collagen matrix implant (Oculusgen ®) Essex RW, Snibson GR, Daniell M, et al. Amniotic membrane grafting in the surgical management of primary pteriygium. Clin Experiment Ophthalmol 2004; 32: Ozdamar Y, Mutevelli S, Han U, et al. A comparative study of tissue glue and Vycril suture for closing-limbal conjunctival autografts and histologic evaluation after pterygium excision. Cornea 2008; 27: Karalezli A, Kucukerdonmez C, et al. Fibrin glue versus sutures for conjunctival autografting in pterygium surgery: a prospective comparative study. Br J Ophthalmol 2008; 92: Servicio Oftalmología Hospital 12 de Octubre 10

11 Ophthalmlogy Department Hospital 12 de Octubre
PURPOSE CONCLUSIONS MATERIALS RESULTS CONCLUSIONS CONCLUSIONS Biodegradable collagen matrix implant seems to be a safe and effective disposal for pterygium surgery. It is an easy surgical technique and implies a reduction in surgery time comparing with other procedures. More studies should be done in order to obtain more conclusive data. Ophthalmlogy Department Hospital 12 de Octubre 11

12 Servicio Oftalmología Hospital 12 de Octubre
Thanks a lot for your attention Nerea Sáenz Madrazo, MD, PhD. Servicio Oftalmología Hospital 12 de Octubre 12


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