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Microdermabrasion with and without aluminum oxide crystal abrasion: A comparative molecular analysis of dermal remodeling  Darius J. Karimipour, MD, Sewon.

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Presentation on theme: "Microdermabrasion with and without aluminum oxide crystal abrasion: A comparative molecular analysis of dermal remodeling  Darius J. Karimipour, MD, Sewon."— Presentation transcript:

1 Microdermabrasion with and without aluminum oxide crystal abrasion: A comparative molecular analysis of dermal remodeling  Darius J. Karimipour, MD, Sewon Kang, MD, Timothy M. Johnson, MD, Jeffrey S. Orringer, MD, Ted Hamilton, MS, Craig Hammerberg, PhD, John J. Voorhees, MD, Gary Fisher, PhD  Journal of the American Academy of Dermatology  Volume 54, Issue 3, Pages (March 2006) DOI: /j.jaad Copyright © 2006 American Academy of Dermatology, Inc. Terms and Conditions

2 Fig 1 Negative pressure with crystals induces c-Jun mRNA at 4 and 8 hours, whereas negative pressure alone results in minimal induction as quantified by RT-PCR (N = 10; each subject served as his or her own control). Asterisk, P < .05 versus no treatment control. Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © 2006 American Academy of Dermatology, Inc. Terms and Conditions

3 Fig 2 Elevation of TNF-α gene expression at 4 and 8 hours after treatment with negative pressure and abrasion. Minimal induction occurs with negative pressure alone as quantified by RT-PCR (N = 10; each subject served as his or her own control). Asterisk, P < .05 versus no treatment control. Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © 2006 American Academy of Dermatology, Inc. Terms and Conditions

4 Fig 3 Elevation of IL-1β gene expression at 4 hours after treatment with negative pressure and abrasion. Minimal induction occurs with negative pressure alone as quantified by RT-PCR (N = 10; each subject served as his or her own control. Asterisk, P < .05 versus no treatment control. Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © 2006 American Academy of Dermatology, Inc. Terms and Conditions

5 Fig 4 Elevation of MMP-1 gene expression after treatment with negative pressure and crystal abrasion and negative pressure alone (N = 10; each subject served as his or her own control) Asterisk, P < .05 versus no treatment control. Quantitatively higher gene expression is noted after treatment with negative pressure and crystal abrasion when compared with negative pressure alone (double asterisk, P < .05 vs time-matched control). Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © 2006 American Academy of Dermatology, Inc. Terms and Conditions

6 Fig 5 Elevation of MMP-3 gene expression after treatment with negative pressure and abrasion and negative pressure alone (N = 10; each subject served as his or her own control). Asterisk, P < .05 versus no treatment control. Quantitatively higher gene expression is noted after treatment with negative pressure and crystal abrasion when compared with negative pressure alone (double asterisk, P < .05 vs time-matched control). Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © 2006 American Academy of Dermatology, Inc. Terms and Conditions

7 Fig 6 Elevation of MMP-9 gene expression after treatment with negative pressure and crystal abrasion at 8 and 24 hours compared with minimal induction with negative pressure alone (N = 10; each subject served as his or her own control). Asterisk, P < .05 versus no treatment control. Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © 2006 American Academy of Dermatology, Inc. Terms and Conditions

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