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Interpenetrating Networks for Delivery Systems
Client: Professor W. John Kao, School of Pharmacy & Department of Biomedical Engineering Advisor: Professor Naomi Chesler, Department of Biomedical Engineering Ashley Huth Claire Flanagan Adam Rieves Jon Sass
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Overview Background Information Problem Statement Design Requirements
Interpenetrating Networks (IPNs) Competing Products Past Semester Problem Statement Design Requirements Proposed Designs Future Work Questions
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Problem Statement To design a novel delivery mechanism to reconstitute the components of an interpenetrating network (IPN).
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Background: IPNs What is an IPN? A bioactive wound dressing for
Conventional Dressings Irregular Wound What is an IPN? A bioactive wound dressing for large surface area wounds *Kao, W.J.
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Background: IPNs IPNs are composed of multiple components Kao, W.J.
Covalently Linked Therapeutic(s) and/or Cell Adhesion Ligands Soluble Therapeutic(s) Biodegradable Gelatin Backbone PEG-diacrylate (2-3.4 kDa ) in situ UV curing Solution (drugs + matrix component) Kao, W.J.
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Clinical Application Benefits Issues Biocompatible
Moist healing environment Conforms to irregular wounds Covers large surface area wounds Delivers drug cocktails Issues Heat Uneven administration Lengthy application process
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Current Administration Technique
1 Mix Ingredients/ drug(s) in single container 2 Heat Components pegDA Gelatin Photoinitator Water 3 Inject Syringe is use to administer solution 4 Cure in 30 sec to obtain a rubbery film 7 Clean 6 Sustained Release while the IPN biodegrades 5 Cover Day 7 3 1 *Kao, W.J
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Last Semester This Semester
Focused on optimizing IPN solution composition Gelatin dissolution impacts efficacy & administration of IPNs Integrated laboratory & design-based research Developed IPN recipe Modified IPN administration This Semester Administration technique Product packaging Further laboratory research
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Design Requirements Minimal preparation and effort required to administer the IPN Compartmentalization Even spray pattern Uniform solution Straightforward mixing procedure Disposable Can be sterilized Low-cost Few parts
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Competing Products Duoject Medical Systems Inc. Debiotech U-Mix
Inter-Vial Debiotech Clip’n’ject U-Mix Travel Bottle Hansplast Spray Bandage
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Design 1: Syringe Liquid in plunger Powder stored in barrel
Mechanism to release liquid into powder Hand mixing Hand powered delivery Luer-Lock spray tip
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Design 1: Syringe Pros Cons All in one packaging Easy application
Controllable spray rate Cons Custom manufacturing required Moving parts
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Design 2: Pressurized Bottle
Manual pressure vacuum Unique cap design Facilitates stirring mechanism Perforated seal
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Design 2: Pressurized Bottle
Pros Parts readily available Few modifications necessary Spray is sustained for approx. 20 sec Cons Pressure building is laborious All parts must be packaged separately Pressure feature comes at a cost ($14) Only one size is available
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Design 3: Spray Bottle Threaded straw Blades puncture inner container
Single pump, single spray Includes mixing mechanism
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Design 3: Spray Bottle Pros Cons Incorporates mixing mechanism
Provides slow release of photo-initiator Cons Laborious application technique Non-standard parts
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Design Matrix
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Future Work Test cold-water soluble gelatin
Develop-Manufacture-Test prototype Research photoinitiators Continue patent search
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