1. Mean Platelet Volume (MPV), Neutrophil-to Lymphocyte Ratio (NLR) & Platelets-to-Lymphocyte Ratio (PLR)
In association With Cardiovascular Disease In Hemodialysis
E Paschou1, E Gavriilaki2, E Tsotsiou1, V Mamakou3, A Kalaitzoglou2, N Sabanis1
1General Hospital of Edessa, Edessa, Greece
2Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
3Dromokaiteio Hospital, Athens, Greece
Objectives MPV is a well-known risk factor of cardiovascular disease (CVD) since large platelets produce more prothrombotic factors and aggregate more easily. Meanwhile, NLR and PLR have been recently identified as reliable inflammatory indicators. The aim of this study is to investigate the relationship of these markers with CVD in hemodialysis patients.
Methods Type of Study: Cross-sectional
Population: patients in hemodialysis >3 months
medical history of coronary artery disease (CAD),
peripheral artery disease (PAD)
stroke
Candidate Risk Factors recorded:
age
gender
traditional risk factors of CVD
months under hemodialysis (MUH)
the presence of central venus catheter (CVC)
MPV, NLR and PLR were calculated
The SPSS Version 22 was used for the statistical analysis
CVD
Results:
86 patients (62.8% men) / mean age
CVD 68.6% CAD %
PAD 61.6% stroke %
MPV and NLR:
elevated in patients with DM and CAD
(p<0,05)]
No correlation was observed between PLR
and any of the above parameters.
The existence of CVC was associated with
increased NLR and MPV in older patients.  . DM
nDM
p value
MPV
10.9
10.4
0. 24
NLR
5.3 4
0.004
MPV
NLR DM
CAD
nCAD
p value
MPV 11
10.4
0. 008
NLR 5
4.1
0.05 DM
CAD
PAD
stroke HP
MPV
0.024
0.008
0.086
0.555
0.997
NLR
0.004
0.05
0.379
0.063
0.462
PLR
0.225
0.636
0.883
0.059
0.121
MPV
NLR
CAD
Conclusions MPV and NLR are associated with CAD and DM, a relationship that implies a status of inflammation and endothelial dysfunction. PLR which depends on the count of platelets that are usually reduced in hemodialysis patients is not associated with CVD parameters