1. Living Longer Ageing Well Dr Maeve Rea
Department of Geriatric Medicine

2. Nonagenarian Numbers are growing

3. Life Expectancy across World

4. In proportional terms, gains in life expectancy will be higher at older ages

5. Northern Ireland Nonagenarians

6. Projected Populations -2044

7. What do we know about Nonagenarians?

8. The older you get the sicker you get ? Is this true?

9. What is the Evidence?

10. OKINAWA Study 25 year study of the world’s longest-lived population
Largest number of centenarians in the world
Equal numbers of males and females

11. Okinawa Study Young arteries (cholesterol <4 umols/l)
Diet with lots of fresh vegetables
Exercise in abundance
Good family and social support

12. The Danish 1905 Cohort Survey
2,262 Nonagenarians
Functional Status and Self-Rated Health

13. Danish 1905 Cohort Activities of Daily Living Scale
50% men
41% women were not disabled
19% men
22% women were severely disabled

14. Perls Boston Study 350+ centenarians
Time to onset of age-related diseases
Three profiles emerged from their health history

15. Survivors, Delayers, Escapers

16. Which factors which contribute to ‘successful ageing’

17. BELFAST Elderly Subjects
250 apparently well nonagenarian subjects were recruited as part of the Belfast Elderly Longitudinal Free-living Aging STudy (BELFAST)
Aged years, Living at home
Mentally well (Folstein >27/30)

18. Cardiovascular risk and ‘successful ageing’

19. Weight
Mean Male Female
Weight kg

20. Blood Pressure mmHg Diastolic 88.2 85.8 88.8
MEAN MALE FEMALE Systolic
mmHg
Diastolic

21. Conclusions in BELFAST study
nonagenarians in the upper range for weight and BMI were 40% more likely to have BP in hypertensive range compared to those with the lower weights

22. Smokers
Few

23. Immunology and ‘successful ageing’

24. Natural Killer Cells in BELFAST study

25. Gunships of the Immune System

26. Natural Killer Cell

27. Natural Killer Cells

28. CYTOKINES BELFAST in BELFAST Study

29. Cytokines out of Balance
Activating
Calming

30. IL-12 activating and increasing

31. Nutrition and ‘Successful Ageing’

32. We are what we eat? What do Nonagenarians eat?
24 hour dietary recall
Lowish in calories
Wide range of nutrition including protein
Often cooked food for self as had done through life

33. What shall we eat?
Sweet potatoes contain sirtuin, a protein signalling molecule that some scientists believe is important in delaying ageing

34. Social Integration

35. Genes and ‘Successful Ageing’

36. ApoE Frequencies BELFAST
Allele E2
Percent ag E3 es E4
MONICA
(2071)
8.3%
(172)
75.8%
(1570)
15.9%
(329)
>90s
(114)
12.2%
(14)
80.3%
(91)
7.5%
(9)
P value
0.047* -
0.0008**

37. Mitochondrial Haplotype J and Longevity

38. Mitochondrial Tree Ross and Rea Debenedictis G et al Ireland Italy
Neimi et al
Finland

39. Genes and Longevity
25-30%

40. GEnetics of Healthy Ageing
-3200 pairs of 90+ brothers and sisters across Europe
EU-funded study
-Study to look at genes for healthy ageing
Dr I Maeve Rea, Principal Investigator Northern Ireland

41. Elderly Sisters Can you help us find a sibling pair/s for GEHA?
Contact Anne, Senior Research Nurse on
(mobile) or pm
or /2153