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Living Longer Ageing Well Dr Maeve Rea
Department of Geriatric Medicine
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Nonagenarian Numbers are growing
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Life Expectancy across World
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In proportional terms, gains in life expectancy will be higher at older ages
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Northern Ireland Nonagenarians
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Projected Populations -2044
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What do we know about Nonagenarians?
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The older you get the sicker you get ? Is this true?
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What is the Evidence?
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OKINAWA Study 25 year study of the world’s longest-lived population
Largest number of centenarians in the world Equal numbers of males and females
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Okinawa Study Young arteries (cholesterol <4 umols/l)
Diet with lots of fresh vegetables Exercise in abundance Good family and social support
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The Danish 1905 Cohort Survey
2,262 Nonagenarians Functional Status and Self-Rated Health
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Danish 1905 Cohort Activities of Daily Living Scale
50% men 41% women were not disabled 19% men 22% women were severely disabled
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Perls Boston Study 350+ centenarians
Time to onset of age-related diseases Three profiles emerged from their health history
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Survivors, Delayers, Escapers
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Which factors which contribute to ‘successful ageing’
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BELFAST Elderly Subjects
250 apparently well nonagenarian subjects were recruited as part of the Belfast Elderly Longitudinal Free-living Aging STudy (BELFAST) Aged years, Living at home Mentally well (Folstein >27/30)
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Cardiovascular risk and ‘successful ageing’
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Weight Mean Male Female Weight kg
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Blood Pressure mmHg Diastolic 88.2 85.8 88.8
MEAN MALE FEMALE Systolic mmHg Diastolic
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Conclusions in BELFAST study
nonagenarians in the upper range for weight and BMI were 40% more likely to have BP in hypertensive range compared to those with the lower weights
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Smokers Few
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Immunology and ‘successful ageing’
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Natural Killer Cells in BELFAST study
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Gunships of the Immune System
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Natural Killer Cell
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Natural Killer Cells
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CYTOKINES BELFAST in BELFAST Study
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Cytokines out of Balance
Activating Calming
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IL-12 activating and increasing
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Nutrition and ‘Successful Ageing’
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We are what we eat? What do Nonagenarians eat?
24 hour dietary recall Lowish in calories Wide range of nutrition including protein Often cooked food for self as had done through life
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What shall we eat? Sweet potatoes contain sirtuin, a protein signalling molecule that some scientists believe is important in delaying ageing
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Social Integration
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Genes and ‘Successful Ageing’
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ApoE Frequencies BELFAST
Allele E2 Percent ag E3 es E4 MONICA (2071) 8.3% (172) 75.8% (1570) 15.9% (329) >90s (114) 12.2% (14) 80.3% (91) 7.5% (9) P value 0.047* - 0.0008**
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Mitochondrial Haplotype J and Longevity
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Mitochondrial Tree Ross and Rea Debenedictis G et al Ireland Italy
Neimi et al Finland
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Genes and Longevity 25-30%
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GEnetics of Healthy Ageing
-3200 pairs of 90+ brothers and sisters across Europe EU-funded study -Study to look at genes for healthy ageing Dr I Maeve Rea, Principal Investigator Northern Ireland
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Elderly Sisters Can you help us find a sibling pair/s for GEHA?
Contact Anne, Senior Research Nurse on (mobile) or pm or /2153
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