1. W. H. A. M. MULDERS* AND D. ROBERTSON
PROGRESSIVE CENTRALIZATION OF MIDBRAIN HYPERACTIVITY AFTER ACOUSTIC TRAUMA
W. H. A. M. MULDERS* AND D. ROBERTSON
Presenter: Danyi LU
Neuroscience 192 (2011) 753–760

2. spontaneous firing rates (SFRs)
what's new
spontaneous firing rates (SFRs)
Acoustic trauma Central hyperactivity
Early stage: continued peripheral afferent input
Later stage: intrinsically generated within the central nervous system
Abbreviation:
spontaneous firing rates -SFRs
inferior colliculus -IC
central nucleus of the inferior colliculus -CNIC
compound action potential-CAP

3. EXPERIMENTAL PROCEDURES
overall experimental design

4. EXPERIMENTAL PROCEDURES
1.animals
2.anesthesia and surgery
3.inferior colliculus recording*
4.cochlear ablation
5.data analysisi

5. RESULTS-Cochlear thresholds

6. RESULTS-Cochlear thresholds

7. RESULTS-Summary of all data

8. RESULTS-Hyperactivity in CNIC

9. RESULTS-Effects of cochlear ablation on hyperactivity

10. RESULTS-Comparison with shorter recovery data

11. RESULTS-elevated SFRs in CNIC neurons after acoustic trauma were more commonly observed in CF regions of the CNIC that correlate with the frequencies in the cochlea

12. Discussion-differential effect of cochlear ablation at the two stages

13. Recent-onset Tinnitus Long-standing Tinnitus
Significance
Important consequences for possible mechanisms and treatment of tinnitus
Recent-onset Tinnitus
Long-standing Tinnitus