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Kim Peek The Real Rain Man [1/5]

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Presentation on theme: "Kim Peek The Real Rain Man [1/5]"— Presentation transcript:

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3 Kim Peek The Real Rain Man [1/5]

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5 What is dyslexia? - Kelli Sandman-Hurley
What Causes Dyslexia?

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12 Children with ADHD

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17 National Survey of Children's Health
Percent of Youth Aged 4-17 Years Currently Taking Medication for ADHD by State: National Survey of Children's Health

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27 Highly genetic and can be treated by psychostimulants (amphetamine and methylphenidate)
ADHD As A Difference In Cognition, Not A Disorder: Stephen Tonti at TEDxCMU Top 10 Inspirational People with ADHD

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29 Cerebral palsy

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33 Hydrocephalus - Definition, treatment and complications

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38 Comorbidities of ASD

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43 Heritability Greatest Risk Factor For Autism Spectrum Disorders
NEWS   Sep 26, 2017 | Original Story from JAMA Reanalysis of data from a previous study on the familial risk of autism spectrum disorder (ASD) estimates the heritability to be 83 percent, suggesting that genetic factors may explain most of the risk for ASD, according to a study published by JAMA. Studies have found that autism spectrum disorder (ASD) aggregates in families. In a previous study, ASD heritability was estimated to be 50 percent. To define presence or absence of ASD, the study used a data set created to take into account time-to-event effects in the data, which may have reduced the heritability estimates. Using the same underlying data from this study, Sven Sandin, Ph.D., of the Icahn School of Medicine at Mount Sinai, New York, and colleagues used an alternate method (used by previous studies in the field) to calculate the heritability of ASD. The study included a group of children born in Sweden 1982 through 2006, with follow-up for ASD through December The analysis included 37,570 twin pairs, 2,642,064 full sibling pairs, and 432,281 maternal and 445,531 paternal half-sibling pairs. Of these, 14,516 children were diagnosed with ASD. Various models were tested and using the best-fitting model, the ASD heritability was estimated as 83 percent and the nonshared environmental influence was estimated as 17 percent.

44 Common gene variants account for most genetic risk for autism
Roles of heritability, mutations, environment estimated – NIH-funded study Monday, July 21, 2014 Most of the genetic risk for autism comes from versions of genes that are common in the population rather than from rare variants or spontaneous glitches, researchers funded by the National Institutes of Health have found. Heritability also outweighed other risk factors in this largest study of its kind to date. About 52 percent of the risk for autism was traced to common and rare inherited variation, with spontaneous mutations contributing a modest 2.6 percent of the total risk. The bulk of risk, or liability, for autism spectrum disorders (ASD) was traced to inherited variations in the genetic code shared by many people. These and other (unaccounted) factors dwarfed contributions from rare inherited, non-additive and spontaneous (de novo) genetic factors. Source: Population-Based Autism Genetics and Environment Study

45 Check SFARI genes

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47 Autism Autism — what we know (and what we don't know yet) | Wendy Chung

48 Autistic Girl Expresses Unimaginable Intelligence

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50 "Through Our Eyes: Living with Asperger's" (Documentary)
Top 10 Inspirational People With Autism and Asperger Syndrome

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53 Fragile X syndrome

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55 CGG repeats in the FMR1 gene and FMRP protein

56 Potential therapeutic interventions
for fragile X syndrome

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58 Fetal Alcohol Syndrome

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