1. Kidney Transplants in HIV Positive Patients
Protocol Monitoring plan
Patient Survival
1 year endpoint
Monitored monthly with truncated SPRT
90% 1 year (versus 80%)

2. Kidney Transplants in HIV Positive Patients
Protocol Monitoring Plan (continued)
Opportunistic Infections
Expansion to stable patients with prior OI evaluated at 12 and 18 months
Criteria- OI rate demonstrated to be less than 30% via exclusion from 95% confidence interval

3. Kidney Transplants in HIV Positive Patients
Protocol Monitoring Plan (continued)
Graft Survival
Examine 1 year outcome
Monitored monthly with truncated SPRT
Distinguish 75% from 60% 1 year success