1. Self emulsifying Drug Delivery System : Formulation
Dr Trapti Saxena

2. Definition of SEDDS Isotropic mixtures of SMEDDS facilitates Oils
Surfactants
co-solvents/surfactant
SMEDDS facilitates
Generation of large surface area dispersions (micro/nano-emulsions)
Provides increased absorption of poorly water soluble drugs

3. Formulation Components
Oils solubilizes lipophilic drug
Facilitates intestinal lymphatic uptake.
Modified/hydrolyzed vegetable oils-good emulsification systems
MCT are more useful than LCT
Eg :- corn oil, soyabean oil, hydrolyzed corn oil.
OILS
Fatty acid ester/
Medium or long chain triglyceride

4. Formulation Components
Surfactants assist the instantaneous formation of o/w droplets
Non-ionic with high HLB value
High HLB and Hydrophilicity leads to excellent spreading properties
Usual concentration - 30%-60% w/w
Ex Tweens, Labrasol, Labrafac, Cremophore
SURFACTANT

5. Formulation Components
Helps to reduce amount of surfactants
hydrophobic drug in the lipid base.
Lowers interfacial tension.
CO- SURFACTANT & CO- SOLVENTS
Short/medium chain alcohols
Eg. Transcutol, Capmul, Captex
Ethanol, Propylene glycol, Polyethylene glycol

6. Suitable Drug Candidate
BCS CLASS II
Should be soluble in oil phase
Dose should be less
log P>5
DRUG

7. KEY STEP
Only very specific combinations of pharmaceutical excipients lead to efficient self micro-emulsifying systems.
To find a suitable oil surfactant mixture that can dissolve the drug within the required therapeutic concentration.

8. Advantages of Self-emulsifying Systems
Enhanced oral bioavailability.
Liquid or solid dosage forms.
High drug loading efficiency.
Reduced variability including food effects.
Ease of manufacture and scale up.