1. Microemulsion In Drug Delivery Systems
9/12/2018
An-Najah National University Chemical Engineering Department
Microemulsion In Drug Delivery Systems
Prepared by:
Alaa Badran
Ibtihaj Awwad
Hana’a Tareq
Hadeel Suliman
Superior : Dr. Husni Odeh
Submitted to Chemical Engineering Department
Second Semester,
9/12/2018
Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system
Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system

2. Outline Objectives. Microemulsion .
Advantage and disadvantage of microemulsion.
Solubility and Bioavailability.
Earlier study of microemulsion in the drug.
Materials.
Experimental work.
Results and discussion.
Conclusion.
Recommendation.
9/12/2018
Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system

3. 9/12/2018
The objectives
This project aim to design and develop of microemulsion drug delivery system .
Improved the solubility and bioavailability of curcumin drug by using microemulsion.
9/12/2018
Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system
Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system

4. Microemulsions
Microemulsion are liquid dispersions of water and oil that are made homogenous, transparent and thermodynamically stable by the addition of relatively large amounts of surfactant and co-surfactant and having diameter of the droplets in the range of 100 – 1000 A (10 – 100 nm).
9/12/2018
Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system

5. The advantages of Microemulsion
Microemulsions are thermodynamically stable system and the stability allows self-emulsification of the system whose properties are not dependent on the process followed.
Microemulsion have low viscosity compared to other emulsions.
9/12/2018
Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system

6. Microemulsion can improve the efficacy of a drug, allowing the total dose to be reduced and thus minimizing side effects.
microemulsion are easy to prepare and require no significant energy contribution during preparation. 
9/12/2018
Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system

7. The disadvantage of Microemsultion
Use of a large concentration of surfactant and co-surfactant necessary for stabilizing the nano-droplets.
The surfactant must be nontoxic for using pharmaceutical applications .
9/12/2018
Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system

8. Microemulsion stability is influenced by environmental parameters such as temperature and pH.  These parameters change upon microemulsion delivery to patients.
9/12/2018
Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system

9. BIOAVALABILITY
Bioavailability of a drug is largely determined by the properties of the dosage form.
The therapeutic index : ratio of the minimum toxic concentration to the median effective concentration.
Low bioavailability is most common with oral
dosage forms of poorly water-soluble, slowly absorbed drugs.
9/12/2018
Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system

10. SOLUBILITY
Solubility : the amount of a substance that dissolves in a given volume of solvent at a specified temperature.
Poor aqueous solubility .
High lipophilicity.
9/12/2018
Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system

11. Earlier Studies On Microemulsion In The drug
Cyclovir
Labrasol (surfactant)
32%
Plurol Oleique ((co-surfactant 8%
Labrafac (oil)
10%
Water
50%
Bioavailability increases (12.78 times)
9/12/2018
Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system

12. Valsartan
Tween 80
(surfactant)
45%
PEG 400
((co-surfactant
Capmul MCM
(oil)
10%
The release increased more than 90% when compared with marketed formulation
9/12/2018
Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system

13. Glyburide (GLY) Tween-20(sur). Capryol 90 (oil) Water
Transcutol P (co-sur)
Capryol 90 (oil)
Water
9/12/2018
Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system

14. Material The drug: curcmin (anticancer).
The surfactant and co-surfactant: Tween20 (Polysorbate), Spans80(Sorbitan monooleate)
Oil: Jojoba with clove (95%/5%) and clove oil(~100%)
9/12/2018
Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system

15. Microemulsion systems System no.1 Tween 20, Span 80 (Sur. Mix)
Jojoba oil(95%), clove oil (5%)
System no. 2
Tween 20,
span80 (Sur. Mix.)
Clove oil ≃100%
9/12/2018
Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system

16. Microemulsion Preparation
The Procedures
Curcumin Preparation
Microemulsion Preparation
Solubility Test
9/12/2018
Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system

17. Addition af surfactant/ co-surfactant
Addition of oils
Addition of water.
Shaking.
Microemulsion Formulation
9/12/2018
Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system

18. Table(1): Initial concentration values of oil and Sur. Mix
Table(1): Initial concentration values of oil and Sur. Mix. For the two systems
Amount of oil
0.2
0.4
0.6
0.8 1
1.2
1.4
1.6
1.8
Amount of Sur. Mix
9/12/2018
Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system

19. Drug solubility experiments
Drug solubility experiments were carried out based on the previous microemulsion experiments. It was experienced that for:
First system jojoba oil and clove oil:
surfactant/co-surfactant, oil, water(3.01%,27.07%,69.9%).
surfactant/co-surfactant, oil, water (6%,24.28%,69.72%).
surfactant/co-surfactant, oil, water(9.02%,21.11%,69.87%) .
9/12/2018
Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system

20. Second system clove oil :
surfactant/cosurfactant,oil, water (3%, 27.14%, 69,86%).
surfactant/cosurfactant,oil, water(6.02%,24.06%,69.92%).
surfactant/cosurfactant,oil, water (9.01%,21.15%,69.84%) .
9/12/2018
Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system

21. Results and Discussion
Due to the addition of water the shape and color of emulsions were changed.(3, 2, 1 phases)
9/12/2018
Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system

22. Results and discussion
9/12/2018
Figure(1): Triangle Phase Diagram of oil , Sur. Mix. And Water

23. The highest solubility of curcumin 5mg/ml is found at (20%,10%,70%): (S mix./oil/water) microemulsion system.
9/12/2018
Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system

24. Conclusion
Microemulsion is excellent candidate as potential drug delivery system.
The microemulsion system occurred at (20% Smix ,10% oil ,70% water).
The highest drug solubility of curcumine 5mg/ml is found at (20%/10%/70%) : (Smix/oil/water) microemulsion system.
9/12/2018
Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system

25. Recommendations
1. Microemulsion method is one of the best method of drug delivery to increase bioavailability of drug.
2. Deep study must be done for each material used in preparation
of ME.
3. Careful dealing with components while adding them to the system.
9/12/2018
Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system

26. 4. Use pre-calibrated devices for measuring amounts of components.
5. Use suitable shaking device that offer gentle mixing for several tubes that save time and effort.
6. Use Pure Water in Preparation of ME
9/12/2018
Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system

27. Thank You
9/12/2018
Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system