1. Figure 1 What is the relationship between SLE and SS?
1. Both SLE and SS very similar genetics and antibodies;
Both have Type I IFN signature
SLE SS
3. SS is characterized by lymphoid infiltrates
in glands and other tissues
so lymphocyte aggressive
4. Homing receptors--
-- to get lymphocytes to tissues
-- Perpetuation of local immune response
to produce Antibody to SS-A/SS-B
-- Increased risk Lymphoma
2. SLE is characterized by
Immune Complexes
 Renal glomeruloneph.
 Hemolytic anemia
 Thrombocytopeniaq

2. However, SS and SLE do have some distinct differences
SS is characterized by infiltration of lymphocytes into ocular and salivary glands,
so it is more lymphocyte aggressive,
and may also includes other systems such as
 lung (pneumonitis),
 kidney (interstitial nephritis),
 neurological (central and peripheral)
 lymphoproliferative (features) (lymphoma)

3. Figure 3 Extraglandular manifestations
Sjogren’s syndrome
 Skin-hyperglob purpura…….
 Lung-interstitial pneumonitis
 Renal-interstitial nephritis…
 Cardiac-pulmonary hypertension..
 Hematologic--lymphoma….
 Neurologic-peripheral neuropathy
 Esophageal-dysphagia and tracheal reflux
SLE
 Skin-leukocytoclastic vasculitis
 Lung-pleural effusions
 Renal-glomerulonephritis
 Cardiac-pericarditis
 Hematologic-ITP, hemolytic anemia
 Neuropathy-mononeuritis multiplex