1. Potential effects of 10kg wt loss in Type 2 diabetes
Mortality >20% fall >30% fall in DM related death >40% fall in obesity related death BP Sys BP 10mmHg, Dia 20mmHg Glucose 50% fall in Fasting glucose Lipid Profile 10% fall in Total Cholesterol 15% fall LDL-C 30% Triglyceride 8% Rise in HDL-C
Magnitude of expected benefit
Br J Diab Vasc Dis 11(1) Jan 2011

2. UKPDS -What happens after 18 years
UKPDS -What happens after 18 years ? Remember: No difference in Hba1c betweeen groups after initial 8 years
Favours early glucose lowering