1. Enhancement of study programs in Public Health Law, Health
ERASMUS+ KA2 PROJECT:
Enhancement of study programs in Public Health Law, Health
Management, Health Economics and Health Informatics in Montenegro
Festival of Medical Achievements
1st PH-ELIM National Conference: Modern Trends in Public Health: Experience and Practices, Research and Innovation
20 October 2017, Podgorica, Montenegro
Project web site:

3. Medical Informatics for Enabling Systems Medicine
Petra Knaup University of Heidelberg, Germany
Institute of Medical Biometry and Informatics
Project web site:

4. Institute of Medical Biometry and Informatics
12 departments /centers
11 institutes
Heidelberg
University
Hospital
12,000 staff
1,500 physicians
1,900 beds
65,000 inpatients
1, outpatient visits p.a.
Institute of Medical Biometry and Informatics
3,500 Medical students
200 PhD-theses p.a.
50 Habilitations p.a.

5. digitalisation personalized medicine big data
Current Trends
digitalisation
personalized medicine
big data

6. digital age computer-based processes digital agenda
by: Wilgengebroed
Digitalisation
digital age
computer-based processes
digital agenda
Tim Reckmann  / pixelio.de

7. Personalized Medicine
therapy A
prognosis: responder to therapy A
therapy B
diagnostic test
prognosis: non-responder to therapy B
therapy C
prognosis: inacceptable side effects

8. Example Multiple Myeloma
Heterogeneous survival times: from few months to more than 15 years
Only 30 % of patients respond to the most effective therapies.
About 40 % of patients, which are treated with an effective drug, develop a neuropathie.

9. Big Data traditional: driven by hypotheses Big Data: data-driven
research question
acquisition of data
testing the hypotheses
Big Data: data-driven
data are available
search for new knowledge in the data

10. digitalisation personalized medicine big data
Trends
digitalisation
personalized medicine
big data
 new data
 new information
 new knowledge

11. Medical Informatics
… is the science of systematic management, archiving, processing and presentation of
Data, Information und Knowledge in medicine and healtcare.
It is motivated by enabling high quality patient care.
according to

13. System‘s Medicine
„… is the application of systems biology approaches to medical research and medical practice.
Its objective is to integrate a variety of biological / medical data … using the power of computational and mathematical modelling, to enable understanding of the pathophysiological mechanisms, prognosis, diagnosis and treatment of disease.“
Auffray C, Balling R, Benson M, Bertero M, Byrne H, Cascante M et al. From Systems Biology to Systems Medicine. Brussels , 2010.

14. patient generated data
clinical data
research data
patient generated data
knowledge
results
images
reports …
clinical trials
registries
biobanking
genomics …
nutrition
lifestyle
fitness
wellness …
publications
case reports
guidelines

15. Heterogeneity of Data harmonization – semantic level
ETL-processes – syntactic level
application system – user level

16. case base knowledge base rule base indi v idua l p atien t d a
omi cs d a t G W A S
(SNP)
RNAseq
GEP cy o g
eneti
indi v
idua l p
atien t d a
individualized r
the a py
omi cs d a t c
lini l
case
base
knowledge
base c
lini a l d t i m
agi n g s
ide ef f
ect
Lab
rule base
litera- ture
medical
guide- lines
systems
biology models
reasoning
Systemmedizin
Management
Architektur
Prototyp
Diskussion

17. Information Management
well-defined information management processes
comprehensive information
up-to-date information
cyclic data management approach
including knowledge-base
dynamically updated
ETL - procedures

18. Data Representation Decision Support User Interface
IT-Architecture
Data Representation
Decision Support
User Interface

19. IT Architecture
preprocessing of data and knowledge from heterogeneous sources: harmonisation, transformation, storage
application of knowledge-based procedures on data and knowledge: e.g. rule-based, case-based, systems biology models
supporting the physician and scientist: transparent, timely and reproducible decisions
Systemmedizin
Management
Architektur
Prototyp
Diskussion

21. Summary of our Approach
Information and IT-management for systems medicine
flexible approach
heterogeneous data sources
enable different knowledge-based concepts
dynamic updates
innovative user interfaces

22. Constitution of the World Health Organization: Principles
physical
Health is a state of complete physical, mental and social well-being and not merely the absence of disease or infirmity.
mental
social
well- being

23. Constitution of the World Health Organization: Principles
The enjoyment of the highest attainable standard of health is one of the fundamental rights of every human being without distinction of race, religion, political belief, economic or social condition. …

24. Big Data Personalized Medicine Digitalisation
Take Home Message
Big Data
Personalized Medicine
Digitalisation
Smart Data
Systems Medicine
Application Systems