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Jorge Iván Castillo-Quan, T. Keith Blackwell  Cell 

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Presentation on theme: "Jorge Iván Castillo-Quan, T. Keith Blackwell  Cell "— Presentation transcript:

1 Metformin: Restraining Nucleocytoplasmic Shuttling to Fight Cancer and Aging 
Jorge Iván Castillo-Quan, T. Keith Blackwell  Cell  Volume 167, Issue 7, Pages (December 2016) DOI: /j.cell Copyright © Terms and Conditions

2 Figure 1 Inhibition of mTORC1 by Metformin
By disrupting mitochondrial energetics, metformin alters passive transport through the nuclear pore complex. This prevents RagC from transiting through the nucleus, and acquiring the GDP-bound active state necessary for mTORC1 activation. Inhibition of mTORC1 increases transcription of ACAD10, in part through SKN-1/Nrf2. ACAD10 inhibits growth and extends lifespan in C. elegans, and reduces human cancer cell viability. Cell  , DOI: ( /j.cell ) Copyright © Terms and Conditions

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