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Volume 33, Issue 6, Pages (December 2014)

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1 Volume 33, Issue 6, Pages 1122-1126 (December 2014)
Dietary thylakoids suppress blood glucose and modulate appetite-regulating hormones in pigs exposed to oral glucose tolerance test  Caroline Montelius, Katarzyna Szwiec, Marek Kardas, Liudmyla Lozinska, Charlotte Erlanson-Albertsson, Stefan Pierzynowski, Jens F. Rehfeld, Björn Weström  Clinical Nutrition  Volume 33, Issue 6, Pages (December 2014) DOI: /j.clnu Copyright © 2013 The Authors Terms and Conditions

2 Fig. 1 Blood glucose following an oral glucose tolerance test (OGTT) in pigs, with or without supplementation of 0.5 g/kg body weight of thylakoids, resulted in significantly lower blood glucose levels the first hour, and no late postprandial hypoglycaemia (120–360 min) following the thylakoid OGTT (○), compared to the control OGTT (▴) (p < 0.05, calculated with AUC). Data are mean ± SEM, in a cross-over design in six pigs. Statistical differences between thylakoid and control OGTT is indicated by **p < 0.01 and ***p < 0.001 (calculated with Bonferroni corrected 2-way Anova). Clinical Nutrition  , DOI: ( /j.clnu ) Copyright © 2013 The Authors Terms and Conditions

3 Fig. 2 Plasma insulin following an oral glucose tolerance test (OGTT) in pigs, with or without supplementation of 0.5 g/kg body weight of thylakoids, resulted in lower levels of p-insulin during the first hour, and elevated levels from 120 to 360 min after the thylakoid OGTT (○) compared to the control OGTT (▴) (p < 0.1, calculated with AUC). Data are mean ± SEM, in a cross-over design in six pigs. Clinical Nutrition  , DOI: ( /j.clnu ) Copyright © 2013 The Authors Terms and Conditions

4 Fig. 3 Secretion of plasma cholecystokinin (CCK) after an oral glucose tolerance test (OGTT) in pigs with or without supplementation of 0.5 g/kg body weight of thylakoids, resulted in significantly increased levels of p-CCK 30 min after the thylakoid OGTT (○), compared to the control OGTT (▴). The secretion of p-CCK was also increased during the complete time period of 0–360 min for the thylakoid OGTT, compared to control OGTT (p < 0.1, calculated with AUC). Data are mean ± SEM, in a cross-over design in six pigs. Statistical differences between thylakoid and control OGTT is indicated by *p < 0.05 (calculated with Bonferroni corrected 2-way Anova). Clinical Nutrition  , DOI: ( /j.clnu ) Copyright © 2013 The Authors Terms and Conditions

5 Fig. 4 Secretion of plasma ghrelin after an oral glucose tolerance test (OGTT) in pigs with or without supplementation of 0.5 g/kg body weight of thylakoids, resulted in significantly decreased levels of p-ghrelin from 120 to 240 min following the thylakoid OGTT (○), compared to control OGTT (▴). The secretion of p-ghrelin was also suppressed during the complete time period of 0–360 min for the thylakoid OGTT, compared to the control OGTT (p < 0.1, calculated with AUC). Data are mean ± SEM, in a cross-over design in six pigs. Statistical differences between thylakoid and control OGTT is indicated by **p < 0.01 and ***p < 0.001 (calculated with Bonferroni corrected 2-way Anova). Clinical Nutrition  , DOI: ( /j.clnu ) Copyright © 2013 The Authors Terms and Conditions


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