1. Volume 105, Issue 1, Pages 106-113 (January 2011)
Serum and BALF YKL-40 levels are predictors of survival in idiopathic pulmonary fibrosis 
Nicoline M. Korthagen, Coline H.M. van Moorsel, Nicole P. Barlo, Henk J.T. Ruven, Adrian Kruit, Michiel Heron, Jules M.M. van den Bosch, Jan C. Grutters 
Respiratory Medicine 
Volume 105, Issue 1, Pages (January 2011)
DOI: /j.rmed
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2. Figure 1
Serum YKL-40 levels in patients and healthy controls. In controls, serum YKL-40 levels were significantly higher (P < 0.01) in the GG group (n = 46) than in the AG group (n = 25). The effect of genotype on serum levels in patients was less pronounced (P = 0.07).
Respiratory Medicine  , DOI: ( /j.rmed )
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3. Figure 2
BALF YKL-40 levels in patients and controls. BALF YKL-40 levels were not associated with genotype in controls. In patients, BALF YKL-40 levels were significantly higher (P = 0.01) in the GG group (n = 28) than in the AG group (n = 18).
Respiratory Medicine  , DOI: ( /j.rmed )
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4. Figure 3
Correlation between Serum and BALF YKL-40 levels in IPF patients (n = 58). R2 = 0.09 P < 0.05.
Respiratory Medicine  , DOI: ( /j.rmed )
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5. Figure 4
Kaplan–Meier survival analysis grouped by baseline YKL-40 levels. Patients that were still alive, that were transplanted or died from a cause unrelated to IPF were censored in the survival analysis. (A) Patients with high serum YKL-40 had significantly worse survival estimates than patients with low serum YKL-40 (P < 0.01, χ2 = 6.77). (B) Patients with high BALF YKL-40 had significantly worse survival estimates than patients with low BALF YKL-40 (P < 0.01, χ2 = 7.81). (C) In the group with both low serum YKL-40 and low BALF YKL-40 there were no IPF related deaths within 48 months after diagnosis. Patients with both high serum YKL-40 and high BALF YKL-40 had significantly worse survival estimates than patients who had either high serum YKL-40 or high BALF YKL-40 (p < 0.01, χ2 = 13.09).
Respiratory Medicine  , DOI: ( /j.rmed )
Copyright © 2010 Elsevier Ltd Terms and Conditions