1. Abhyudai Singh absingh@udel.edu
Systems-level modeling of genetic circuits
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Abhyudai Singh

2. Genetic circuits exhibit stochastic behavior thermal noise; low-copy numbers (shot noise)
Suter et al. Science 2011
How do circuits robustly perform biological function? Mechanisms for buffering stochastic fluctuations? Can fluctuations reveal information about underlying circuits?

3. Building tools for stochastic modeling of genetic circuits
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Dynamical Systems; Control Theory; Stochastic Hybrid Systems; Queuing Theory; Statistical Physics…….
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Data
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Protein level/cell

4. Cell-fate decision in the HIV model system
HIV Infection
Lysis
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GFP
The title of my talk is …
This talk will be somewhat different than the paper that appears in the proceedings because
I’ll be somewhat tutorial and concentrate much more on the motivation and background behind this work
and only at the end I’ll tell you about a new result that we obtained recently and that you’ll find in the proceedings paper
This seemed more appropriate for a workshop like this.
If some of you in the audience are very familiar with systems biology, I apologize in advance because in the talk I’ll go through very basic material.