1. Amyloid β1–43 Accumulates in the Lens Epithelium of Cortical Opacification in Japanese Patients
Invest. Ophthalmol. Vis. Sci ;58(7): doi: /iovs
Figure Legend:
Gene expression of (A) APP, (B) BACE1, (C) PS1, (D) PS2, (E) ADAM10, (F) NEP, and (G) ECE1 in the lens epithelium of cataract patients with or without cortical opacification. Open columns: transparent lens epithelium. Closed columns: opaque lens epithelium. Clear, age, 64.2 ± 7.1 years, n = 6; cataract patients with cortical opacification, age, 73.8 ± 1.9 years, opacity score 4.82 ± 0.35, n = 11; cataract patients without cortical opacification, age, 68.9 ± 3.7 years, opacity score 3.20 ± 0.40, n = 15. *1P < 0.05 versus clear for each group. *2P < 0.05 versus mixed-cataract without cortical opacification for each group. The expression of APP mRNA in mixed-cataract patients with cortical opacification was significantly higher than in normal donors or mixed-cataract patients without cortical opacification.
Date of download: 12/29/2017
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