1. SYMPATHETIC NERVOUS SYSTEM
TRO
DR. K.C.SWAIN
PROF. & HEAD
DEPT. OF PHARMACOLOGY

3. SYMPATHOMIMETIC [ADRENERGIC AGONIST] AGENTS/DRUGS.
These drugs or agents when administered produce the effects which are mimic or similar to the effects produced as a result of activation of sympathetic nervous system.

4. Most of these agents posses either an intact or partially substituted amino { NH2} groups in their chemical structures for which they are often called as sympathomimetic amines.

5. MIXED ACTING {DIRECT+ INDIRECT}
CLASSIFICATION OF {ADRENERGIC AGONIST } SYMPATHOMIMETIC agents according to mechanism of action. NO. I
DIRECTLY ACTING
CATECHOLAMINES
NONCATECHOLAMINES
INDIRECTLY ACTING
MIXED ACTING {DIRECT+ INDIRECT}
AMPHETAMINE
TYRAMINE
dihydroxybenzene agents having “OH” [HYDROXYL} GROUPS AT ADJACENT{ BOTH} 3RD & 4TH POSITIONS OF BENZENE RING .
which do not posses “OH” GROUP AT BOTH ADJACENT POSITION OF BENZENE RING BUT ONLY AT ONE POSITION EITHER 3RD OR 4TH OR 5TH.
EPHEDRINE
METARAMINOL
DOPAMINE
MEPHENTERMINE
ENDOGENEOUS
SYNTHETIC
ADRENALINE
NOR-ADRENALINE
DOPAMINE
DOBUTAMINE
ISOPRENALINE
ETHYLNORADRENALINE
PRENALTEROL
ISOETHARINE

6. CLASSIFICATION OF NON-CATECHOLAMINES.
SELECTIVE α 1 AGONIST.
SELECTIVE α2 AGONIST
SELECTIVE β2 AGONIST
NASAL DECONGESTANT
NASAL DROPS : 1.XYLOMETAZOLINE-.05-1% TETRAHYDOZOLINE % OXYMETAZOLINE-.05-1% NAPHAZOLINE { NOT TO BE USED. PRIVINE.} 5.PHENYLEPHRINE 6.TUAMINOHEPTANE SULPHATE PROPYLHEXEDRINE NASAL INHALER{ 250 mg} ORAL ROUTE : PSEUDOEPHEDRINE PHENYLEPHRINE 10.PHENYLPROPANOLAMINE.
1.SALBUTAMOL TERBUTALINE 3.METAPROTERENOL RITODRINE FENOTEROL QUINATERANOL
7.FORMOTEROL{ t1/2=12hrs.RAPID ACTION } SALMETEROL{t½=12hrs. Slow action} ARFORMOTEROL{R,R isomer of formoterol & twice more potent than formoterol ,long acting, given by nebulization] BITOLTEROL
1.METHOXAMINE 2.PHENYLEPHRINE 3.MEPHENTERMINE 4.METARAMINOL
5.MIDODPINE
1.METHYLDOPA 2.CLONIDINE APRACLONIDINE
4.GUANABENZ TIZANIDINE{MUSCLE RELAXANT} 6.BRIMONIDINE { DECREASES I.O.P. }

7. Classification of sympathomimetc agents on the basis of therapeutics(I).
CARDIAC INOTROPICS 1.DOBUTAMINE 2.DOPAMINE ADRENALINE ISOPRENALINE.
BRONCHODILATORS : ADRENALINE ISOPRENALINE 3.EPHEDRINE SELECTIVE β2—.AGONISTS.
LOCAL VASOCONSTRICTORS : ADRENALINE 2.PHENYLEPHRINE
VASOPRESSOR AGENTS : NOR-ADRENALINE 2.PHENYLEPHRINE METARAMINOL 4.MEPHENTERMINE METHOXAMINE 6.METHOXYPHENA MINE.

8. ANTIANAPHYLACTIC/ANTI ALLERGIC
Classification of sympathomimetic agents on the BASIS OF Therapeutics [ II]
UTERINE RELAXANTS
C.N.S.
STIMULANTS
ANOREXIANTS.
NASAL DECONGESTANTS
AGENTS.
ANTIANAPHYLACTIC/ANTI ALLERGIC
Adrenaline
Ephedrine
Ritodrine
Salbutamol
Isoxsuprine
Fenfluramine
Dextroamphetamine
Phentermine
sibutramine
Amphetamine
Ephedrine
IN - I

9. ROLE OF PRESYNAPTIC ALPHA-2 & BETA -2 ON HOMOTROPIC & HETROTROPIC RECEPTORS