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Overview of the TGF-β signaling pathway

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Presentation on theme: "Overview of the TGF-β signaling pathway"— Presentation transcript:

1 Overview of the TGF-β signaling pathway
Overview of the TGF-β signaling pathway. TGF-β binds to TβR-II, which then phosphorylates TβR-I, thereby activating it. TβR-I then phosphorylates Smad2 or Smad3, allowing them to form homo-oligomers or hetero-oligomers with Smad4. Hetero-oligomeric complexes of Smad4 with Smad2 or Smad3 associate with DNA-binding proteins. These complexes then bind to sequences in the promoter regions of genes under TGF-β control, regulating their transcription. Source: Juvenile Polyposis Syndrome, The Online Metabolic and Molecular Bases of Inherited Disease Citation: Valle D, Beaudet AL, Vogelstein B, Kinzler KW, Antonarakis SE, Ballabio A, Gibson K, Mitchell G. The Online Metabolic and Molecular Bases of Inherited Disease; 2014 Available at: Accessed: December 29, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved

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