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Elevated Translocator Protein in Anterior Cingulate in Major Depression and a Role for Inflammation in Suicidal Thinking: A Positron Emission Tomography.

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Presentation on theme: "Elevated Translocator Protein in Anterior Cingulate in Major Depression and a Role for Inflammation in Suicidal Thinking: A Positron Emission Tomography."— Presentation transcript:

1 Elevated Translocator Protein in Anterior Cingulate in Major Depression and a Role for Inflammation in Suicidal Thinking: A Positron Emission Tomography Study  Sophie E. Holmes, Rainer Hinz, Silke Conen, Catherine J. Gregory, Julian C. Matthews, Jose M. Anton-Rodriguez, Alexander Gerhard, Peter S. Talbot  Biological Psychiatry  Volume 83, Issue 1, Pages (January 2018) DOI: /j.biopsych Copyright © 2017 Society of Biological Psychiatry Terms and Conditions

2 Figure 1 Regional mean [11C](R)-PK11195 binding potential (BPND) in patients with major depressive disorder (MDD) and control subjects, showing statistically significant elevations in the anterior cingulate cortex (ACC) but not in the prefrontal cortex (PFC) or insula. Asterisk (*) indicates significant at p < .05. Biological Psychiatry  , 61-69DOI: ( /j.biopsych ) Copyright © 2017 Society of Biological Psychiatry Terms and Conditions

3 Figure 2 Regional [11C](R)-PK11195 binding potential (BPND) in controls, patients with major depressive disorder (MDD) with suicidal thoughts, and patients with MDD without suicidal thoughts. Horizontal bars indicate means. Open circles represent control subjects (n = 13), closed triangles represent patients with MDD with suicidal thoughts (n = 9), and closed circles represent patients with MDD without suicidal thoughts (n = 5). Asterisk (*) indicates significant at p < .05. ACC, anterior cingulate cortex; PFC, prefrontal cortex. Biological Psychiatry  , 61-69DOI: ( /j.biopsych ) Copyright © 2017 Society of Biological Psychiatry Terms and Conditions


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