1. Mean changes in fasting plasma glucose and HbA1c in the Multicenter Metformin Study, Protocol 1
Placebo
Metformin
***p < vs placebo
Sanchez-Rangel and Inzucchi (2017)
Diabetologia DOI /s x
© 1995 Massachusetts Medical Society. Adapted with permission from DeFronzo et al

2. Fasting plasma glucose
Placebo-subtracted adjusted mean changes in fasting plasma glucose and HbA1c over 11 weeks in 451 patients with type 2 diabetes randomised to metformin or placebo
Fasting plasma glucose
HbA1c
Sanchez-Rangel and Inzucchi (2017)
Diabetologia DOI /s x
© 1997 Elsevier, adapted with permission from Garber et al
†p = 0.054, **p < 0.01 and ***p < vs placebo

3. Mean changes in fasting plasma glucose and HbA1c in the Multicenter Metformin Study, Protocol 2
Glibenclamide + metformin
Glibenclamide
Switched from glibenclamide
to metformin
**p < 0.01, ***p < metformin vs glibenclamide; †††p < combination therapy vs glibenclamide
Sanchez-Rangel and Inzucchi (2017)
Diabetologia DOI /s x
© 1995 Massachusetts Medical Society. Adapted with permission from DeFronzo et al