1. Cellular Biology (NGSS: HS-LS1-2)
Tuesday, November 7
Cellular Biology (NGSS: HS-LS1-2)
I will be able to make a claim based on evidence on which type of stem cells we should use
Today’s agenda:
Warm up – as you walk in
Video clip (phenomenon)
Stem cells
Cons and pros of stem cells
Analyzing evidence
Exit slip
WARM UP as you walk in: What is a zygote? What is “cell differentiation”? Be ready to share
SEP 5: use mathematics and computational thinking
Disciplinary core idea: LS2.B: Cycles of Matter and Energy Transfer in Ecosystems
Biomass, trophic levels, ecosystems

2. What questions come to mind
What questions come to mind? On your graphic organizer write down two questions

3. Stem cells What are they? Stem cells are undifferentiated cells
What do they do? They can:
make more stem cells
differentiate into different cell types
This slide explains the basic properties of stem cells and introduces the concept of classification based on potency.
Embryonic stem cells
Adult stem cells

4. Adult stem cells are isolated from tissues of the body
BRAIN
Adult stem cells
are isolated from tissues of the body
can give rise to a limited number of tissues
can reproduce only a limited number of times
are difficult to isolate from tissue
Treatments based on these cells are limited to blood cancers and auto-immune diseases
Less likely to be rejected if injected into a patient
SKIN
HEART
BLOOD
INTESTINE
This slide provides key information about tissue stem cells.
Other points you may wish to raise are:
tissue stem cells are multipotent, meaning they only give rise to a limited number of different tissues
under the right conditions tissue stem cells can be grown in the laboratory
tissue stem cell are widely use in research
treatments based on tissue stem cells are limited to blood cancers like leukeamia and auto-immune diseases (and have been for over 50 years). These treatments involve stem cells obtained from bone marrow and umbilical cord blood
there are many other therapeutic applications of tissue stem cells currently being evaluated but these are not yet clinically proven and widely accepted. For example, clinical trials are underway to use adult stem cells to treat long bone fractures, kidney failure, heart failure, arthritis and cartilage regeneration, just to name a few possible future applications
the use of tissue stem cells in research and in the clinic attracts less controversy than other types of stem cells (eg ES cells) but still require ethics approval to create and use in the laboratory and the clinic.
generally very difficult to isolate
already used to treat patients (certain types of cancers, diseases of the immune system) 4

5. Embryonic stem cells are isolated from human embryos
can give rise to all cell types that make up the body
can reproduce limitlessly
grow easily in a lab
8-cell
blastocyst
fertilised egg
2-cell
egg
Day 0
Day 1
Day 2
Day 3
Day 6
Embryonic stem cells
This slide explains the basic properties of stem cells and introduces the concept of classification based on potency.

6. What are some advantages and disadvantages of these two types of stem cells?
Adavantages and disadvantages

7. Why are stem cells so special?
Stem cells can be used to:
Regenerate tissue (spinal cord, heart tissue and other tissues)
Cure cancer (leukemia and pancreatic cancer)
Cure autoimmune diseases
Test drugs
This slide explains the basic properties of stem cells and introduces the concept of classification based on potency.

8. What is the controversy on stem cells?
Controversy: disagreement, debate, dispute

9. What is the controversy on stem cells?
Removing the stem cells from embryos destroys embryos
Creating human embryos for stem cells is very controversial
Questions of ethics arise because embryos are destroyed as the cells are extracted, such as: When does human life begin? What is the moral status of the human embryo?

10. Something to think about…
SUCCESSFUL STORIES
SCHOLASTIC JESUIT ON STEM CELLS

11. Analyze the material at your table:
Article (sport medicine)
Graphs
Infographic
If hou see smtg advantage or disadvantage, write it down
And answer the questions on your graphic organizer

12. Exit slip – CER (Claim Evidence Reasoning)
Choose either adult stem cells or embryonic stem cells: which cell type should we use?
Make a claim, provide three pieces of evidence and include the reasoning.

13. CER grading rubric

14. More info on stem cells