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Therapeutic Efficacy of Astatine-211–Labeled Trastuzumab on Radioresistant SKOV-3 Tumors in Nude Mice  Stig Palm, Ph.D., Tom Bäck, Ingela Claesson, Anna.

Published byMargareta Eliasson Modified over 6 years ago

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Presentation on theme: "Therapeutic Efficacy of Astatine-211–Labeled Trastuzumab on Radioresistant SKOV-3 Tumors in Nude Mice  Stig Palm, Ph.D., Tom Bäck, Ingela Claesson, Anna."— Presentation transcript:

1 Therapeutic Efficacy of Astatine-211–Labeled Trastuzumab on Radioresistant SKOV-3 Tumors in Nude Mice  Stig Palm, Ph.D., Tom Bäck, Ingela Claesson, Anna Danielsson, Ph.D., Jörgen Elgqvist, Ph.D., Sofia Frost, M.Sc., Ragnar Hultborn, M.D., Ph.D., Holger Jensen, Ph.D., Sture Lindegren, Ph.D., Lars Jacobsson, Ph.D.  International Journal of Radiation Oncology • Biology • Physics  Volume 69, Issue 2, Pages (October 2007) DOI: /j.ijrobp Copyright © 2007 Elsevier Inc. Terms and Conditions

2 Fig. 1 Percentage of injected activity per gram (%IA/g) for intraperitoneally injected astatine-211 (211At)-trastuzumab (∼400 kBq on ∼5 μg monoclonal antibody [mAb]) in organs at 1.3, 3.5, 9, and 19 h (n = 5 for each time point) after injection. Values corrected for radioactive decay and presented as the mean ± standard error of mean (standard error of mean is one standard deviation of mean). ∗Activity concentration in thyroid determined from throat specimens (see “Methods and Materials” section). International Journal of Radiation Oncology • Biology • Physics  , DOI: ( /j.ijrobp ) Copyright © 2007 Elsevier Inc. Terms and Conditions

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