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Systematic review of the association between oil and natural gas extraction processes and human reproduction  Victoria D. Balise, B.S., Chun-Xia Meng,

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Presentation on theme: "Systematic review of the association between oil and natural gas extraction processes and human reproduction  Victoria D. Balise, B.S., Chun-Xia Meng,"— Presentation transcript:

1 Systematic review of the association between oil and natural gas extraction processes and human reproduction  Victoria D. Balise, B.S., Chun-Xia Meng, M.D., Ph.D., Jennifer N. Cornelius-Green, M.S., Christopher D. Kassotis, Ph.D., Rana Kennedy, B.S., Susan C. Nagel, Ph.D.  Fertility and Sterility  Volume 106, Issue 4, Pages (September 2016) DOI: /j.fertnstert Copyright © Terms and Conditions

2 Figure 1 Inclusion flow chart. Summary of literature search strategies, levels of screening, and final inclusion. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © Terms and Conditions

3 Figure 2 Integration of evidence of health effect. Visualization of integration of the evidence of a health effect based on each articles finding and the level of evidence and confidence ratings for endpoints (A) Preterm Birth, (B) Miscarriage, (C) Stillbirth, (D) Low Birth Weight, (E) Birth Defects, (F) Sex Ratio, (G) Semen Quality and Fertility, (H) Paternal Birth Outcomes, (I) Prostate Cancer, (J) Testicular Cancer, (K) Female Reproductive Tract Cancers, and (L) Breast Cancer. The total number of articles for each endpoint is indicated below each chart. Evidence was integrated for each endpoint based on each article's level of evidence and level of confidence. High, moderate, and low level of confidence findings were weighted by multiplying the number of articles by 3 for high, 2 for moderate, and 1 for low for all studies except where noted. *Four studies were not independent of each other and integration of evidence was adjusted (Materials and Methods). ↑ Indicates increased risk. ↓ Indicates decreased risk. **Two studies analyzed the same cohort, only the most recent study was included (Materials and Methods). Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © Terms and Conditions

4 Figure 3 In vitro effect/no effect summary. Summary of the number of in vitro studies reporting effect or no effect on individual steroid hormone receptors including (A) estrogen, (B) androgen, and (C) progesterone. The total number of articles for each endpoint is indicated below each chart. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © Terms and Conditions


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