1. The Effects of PEEP on Oxygenation during One-Lung Ventilation
Author n
End Points
Outcome
Cohen E, et al
J Cardiothorac Vasc Anesth
1996; 10:578-82
[ref 30]
n=18
(prospective)
Hypothesis pts with low PaO2 (<80 mmHg) during OLV may benefit from PEEP 10 cmH2O
n=11 pts with PaO2 <80 mmHg
FiO2 0.5%
OLV PaO2 + PEEP (10)
65 ± ± 32
Ren Y, et al
Anaesth Intensive Care 2008; 36: [ref 35]
n=30 OLV
Best time
Level of PEEP
Group A – 0, 5, 10 cmH2O
B – 5 cm H2O
C – 10, 5, 0 cmH2O
PaO2 lower w/o PEEP
PaO2 better with 5 or 10 PEEP
10 cm H2O PEEP ↑Ppeak and Pplat
Hoftman N, et al
Ann Card Anaesth
2011; 14:
[ref 36]
n=41 OLV
Efficacy of PEEP
Preop predictors of response to PEEP
OLV PEEP, 5 (15 min)
PEEP, 10 (15 min)
PEEP improved arterial oxygenation by ≥20% only
29% (n=12)
Failure to improve oxygenation 71%
Only VT 6.6 ml•kg among responders with PEEP