1. Allosteric Activators
Jared Band
Komal Vadodaria
Lauren Castle
Zeshan Kahn
Period 4

2. Allosteric Regulation
Specific molecules regulate enzyme activity in the cell
The regulatory molecules change an enzyme’s shape
Then, the regulatory molecules bind to another site on the molecule
Result? The function of the active site changes (remember – each enzyme has a specific function provided by a specific “key and lock” to fit specific molecules)
Via noncovalent bonds
ALLOSTERIC REGULATION: a protein’s function is affected by a change in the binding of another molecule along another site

3. Definition Allosteric Activator:
Specific molecules that adapt the shape of an enzyme in order to create more stability within the enzyme.
These activators are unique to specific enzymes
Each enzyme has a specific function
Animated Diagram:

5. So, allosteric activators make an enzyme more stable!
So What?
So, allosteric activators make an enzyme more stable!
allows enzyme to perform specific function better

6. How does this relate to enzymes?
Relating to Our Lives…
Imagine that you have a Math test first period in the morning….
don’t eat breakfast = you do OK
eat breakfast = do even BETTER
food=energy  less distractions
How does this
relate to enzymes?

7. ATP hydrolysis: ADDING A WATER MOLECULE
ATP binds to several catabolic enzymes allosterically  lowers their affinity for substrate and inhibits their activity while ADP acts as an activator of the same enzyme.
If ATP production slows down, ADP accumulates and activates these key enzymes that speed up catabolism, producing more ATP.
Catabolism slows down as ATP molecules accumulate and bind to enzymes, inhibiting them.

8. Video